Abstract
The previously reported earlier onset of pituitary tumours in cross-bred mice inheriting a mutant Rb-1 allele paternally has been ascribed to imprinting of an Rb-1-linked gene. Here, we demonstrate that, as predicted from this mechanism, there is no effect of the parent of origin of the mutation in inbred mice.
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Armstrong, J., Hooper, M. Inbreeding abolishes the effect of parental origin of a mutant Rb-1 allele on pituitary tumorigenesis in mice. Br J Cancer 78, 484–485 (1998). https://doi.org/10.1038/bjc.1998.519
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DOI: https://doi.org/10.1038/bjc.1998.519