Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Experimental Oncology
  • Published:

Response to ICRF-159 in cell lines resistant to cleavable complex-forming topoisomerase II inhibitors

British Journal of Cancer volume 75, pages 816–821 (1997)Cite this article

Abstract

We have studied the relationship between expression of genes implicated in mediating resistance to cleavable complex-forming topoisomerase II (topo II) inhibitors and cellular sensitivity to ICRF-159, a 'catalytic' inhibitor of topo II. Overexpression of the membrane transporters, P-glycoprotein and multidrug resistance-related protein (MRP), or down-regulation of topo IIalpha and/or -beta, did not confer ICRF-159 resistance. Indeed, marked topo IIalpha down-regulation appeared to be associated with collateral sensitivity to ICRF-159. Our results indicate that the resistance mechanisms that pertain to cleavable complex-forming topo II inhibitors and ICRF-159 are distinct. The evidence presented here suggests that topo IIalpha, not topo IIbeta, is more likely to be the major in vivo target for ICRF-159.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Imperial Cancer Research Fund Laboratories, University of Oxford, UK

    SL Davies

Authors
  1. SL Davies
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J Bergh
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. AL Harris
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. ID Hickson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Davies, S., Bergh, J., Harris, A. et al. Response to ICRF-159 in cell lines resistant to cleavable complex-forming topoisomerase II inhibitors. Br J Cancer 75, 816–821 (1997). https://doi.org/10.1038/bjc.1997.146

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/bjc.1997.146

This article is cited by

Search

Advanced search

Quick links