Abstract
Up-regulation of autocrine motility factor receptor (AMF-R) expression has been shown to be associated with invasion and metastasis of experimental tumour systems and human neoplasms. Monoclonal antibodies against AMF-R (gp78) were used to stain 221 primary gastric cancer specimens, and level of expression was examined in relation to pathological stage and prognostic values. In 125 out of 221 (56.6%) patients, gp78 was detected. Expression of gp78 was associated with macroscopic type, lymphatic and venous invasions, and lymph node and peritoneal metastasis. The level of gp78 expression in the cancer specimens was associated with histopathological stage and grade of tumour penetration. Positive gp78 expression was significantly associated with poor prognosis (P < 0.001). This significant relationship remained among patients in stage II and III. The results suggest that gp78 expression could be used as a prognostic marker in gastric cancer patients.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hirono, Y., Fushida, S., Yonemura, Y. et al. Expression of autocrine motility factor receptor correlates with disease progression in human gastric cancer. Br J Cancer 74, 2003–2007 (1996). https://doi.org/10.1038/bjc.1996.667
Issue Date:
DOI: https://doi.org/10.1038/bjc.1996.667
This article is cited by
-
Deacetylation of HSPA5 by HDAC6 leads to GP78-mediated HSPA5 ubiquitination at K447 and suppresses metastasis of breast cancer
Oncogene (2016)
-
The autocrine motility factor receptor is overexpressed on the surface of B cells in Binet C chronic lymphocytic leukemia
Medical Oncology (2011)
-
Glycolysis inhibition for anticancer treatment
Oncogene (2006)
-
Overexpression of autocrine motility factor in metastatic tumor cells: possible association with augmented expression of KIF3A and GDI-β
Laboratory Investigation (2004)
-
Autocrine motility factor-receptor gene expression in lung cancer
The Japanese Journal of Thoracic and Cardiovascular Surgery (2003)