Abstract
The dynamic effect of cis-diamminedichloroplatinum(II) (DPP) and its aquated metabolite (DDP-OH) on a dimyristoylphosphatidylserine (DMPS) model membrane was investigated by pressure tuning vibrational spectroscopy. The native species (DDP-Cl) and the aquated species (DPP-OH) were both observed to bind to the carboxylate group of the serine as evidenced by a frequency shift of 1622-1620 cm-1. However, only DDP-OH was observed to bind to the phosphate group (PO(-)2). The binding of either drug to DMPS resulted in an increased pressure required to halt the reorientational fluctuations of the acyl chains, indicating that the distance between the chains were increased. The two drugs did not partition into the matrix of the hydrophobic section in the model membrane. Collectively, these data suggest that DDP-Cl and DDP-OH are capable of binding to the polar head group of DMPS, resulting in an enlargement of the area of the head and a subsequent increase in the intermolecular distance between the acyl chains.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
This work was presented at the annual American Association for Cancer Research meetings in San Diego, CA, USA, May 19-24 1992 and published as an abstract in the Proceedings of the American Association for Cancer Research.
Rights and permissions
About this article
Cite this article
Taylor, K., Goel, R., Shirazi, F. et al. Pressure tuning infrared spectroscopic study of cisplatin-induced structural changes in a phosphatidylserine model membrane. Br J Cancer 72, 1400–1405 (1995). https://doi.org/10.1038/bjc.1995.521
Issue Date:
DOI: https://doi.org/10.1038/bjc.1995.521
This article is cited by
-
Cisplatin interaction with phosphatidylserine bilayer studied by solid-state NMR spectroscopy
JBIC Journal of Biological Inorganic Chemistry (2010)