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  • Experimental Oncology
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Gene methylation of oestrogen and epidermal growth factor receptors in neoplastic and perineoplastic breast tissues

British Journal of Cancer volume 72, pages 973–975 (1995)Cite this article

Abstract

Oestrogen receptor (ER) and epidermal growth factor receptor (EGFR) gene methylation was evaluated in neoplastic and perineoplastic breast tissues from 20 patients. In both tissues, ER gene methylation was inversely correlated with protein levels, while EGFR gene methylation was not. A preferential ER gene hypomethylation was found in neoplastic tissues, suggesting a significant role in neoplastic transformation.

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Authors and Affiliations

  1. Institute of Biomedical Technology, CNR, Rome, Italy

    E Petrangeli

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  1. E Petrangeli
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  2. C Lubrano
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  3. L Ravenna
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  4. A Vacca
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  5. MR Cardillo
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  6. L Salvatori
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  7. F Sciarra
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  8. L Frati
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  9. A Gulino
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Petrangeli, E., Lubrano, C., Ravenna, L. et al. Gene methylation of oestrogen and epidermal growth factor receptors in neoplastic and perineoplastic breast tissues. Br J Cancer 72, 973–975 (1995). https://doi.org/10.1038/bjc.1995.444

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  • DOI: https://doi.org/10.1038/bjc.1995.444

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