Abstract
In hepatocellular carcinoma, mutation within the p53 gene occurs mainly at codon 249 and its frequency has been associated with exposure to aflatoxin. As Senegal is a country where liver cancer incidence is one of the highest in the world and where people are highly exposed to aflatoxin, we screened 15 liver cancer samples from this country for mutation at codon 249 of the p53 gene. Non-tumoral DNA from the patients showed a wild type genotype. Mutation at codon 249 of the p53 gene was detected in 10 of the 15 tumour tissues tested (67%). This frequency of mutation in codon 249 of the p53 gene is the highest described. These results confirmed that there is an association between countries of high aflatoxin intake and a high frequency of mutation in codon 249 of p53 gene, and that HBV alone does not contribute to these base changes.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Coursaget, P., Depril, N., Chabaud, M. et al. High prevalence of mutations at codon 249 of the p53 gene in hepatocellular carcinomas from Senegal. Br J Cancer 67, 1395–1397 (1993). https://doi.org/10.1038/bjc.1993.258
Issue Date:
DOI: https://doi.org/10.1038/bjc.1993.258
This article is cited by
-
A call for aflatoxin control in Asia
CABI Agriculture and Bioscience (2023)
-
Major genomic mutations driving hepatocellular carcinoma
Genome Instability & Disease (2023)
-
Hepatocellular carcinoma and liver cirrhosis TP53 mutation analysis reflects a moderate dietary exposure to aflatoxins in EspÃrito Santo State, Brazil
Molecular Biology Reports (2013)
-
Serum p53 gene polymorphisms and severity of hepatitis B or C-related chronic liver diseases in Taiwan
Hepatology International (2011)
-
P53 codon 249 mutation and other risk factors among Nigerians with hepatocellular carcinoma
Journal Africain du Cancer / African Journal of Cancer (2010)