Abstract
Immunohistochemical assays have been employed to study the expression of ER, PgR, EGFR and Ki67 immunostaining in normal breast tissue (n = 76). The expression of ER and PgR was highly variable in both pre and postmenopausal women and was characterised by large numbers of apparently negative cells. This was most evident for ER-ICA staining in tissues removed from premenopausal women. PgR levels were highest in the ducts of premenopausal women, while EGFR expression was elevated in both ducts and lobules. Ki67 expression was observed in less than 10% of all normal cells and was suppressed by the menopause in lobular tissue. Tamoxifen therapy (40 mg d-1) did not influence the expression of PgR, EGFR or Ki67 immunostaining in cancer associated normal tissue (n = 17). A significant increase, however, was observed in the mean percentage ER positivity in ductal tissue. No effect of duration of tamoxifen therapy was observed on the expression of the antigens studied.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Walker, K., Price-Thomas, J., Candlish, W. et al. Influence of the antioestrogen tamoxifen on normal breast tissue. Br J Cancer 64, 764–768 (1991). https://doi.org/10.1038/bjc.1991.395
Issue Date:
DOI: https://doi.org/10.1038/bjc.1991.395
This article is cited by
-
Systems pharmacology of mifepristone (RU486) reveals its 47 hub targets and network: Comprehensive analysis and pharmacological focus on FAK-Src-Paxillin complex
Scientific Reports (2015)
-
Model of tumor-associated epigenetic changes of HER2, ER, and PgR expression in invasive breast cancer phenotypes
Tumor Biology (2013)
-
Development of a novel method for measuring in vivo breast epithelial cell proliferation in humans
Breast Cancer Research and Treatment (2005)
-
Morphologic and Immunophenotypic Markers as Surrogate Endpoints of Tamoxifen Effect for Prevention of Breast Cancer
Breast Cancer Research and Treatment (2005)