Abstract
We used RNAase protection and restriction fragment length polymorphism assays to detect activating mutations of c-src in a spectrum of human tumours. No mutations were detected at codons 98, 381, 444, and 530. We conclude that mutational activation is not the mechanism of enhancement of pp60c-src-specific kinase activity found in a number of human cancer types.
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Wang, P., Fromowitz, F., Koslow, M. et al. c-src structure in human cancers with elevated pp60c-src activity. Br J Cancer 64, 531–533 (1991). https://doi.org/10.1038/bjc.1991.344
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DOI: https://doi.org/10.1038/bjc.1991.344