Abstract
We have studied a remarkable family with seven cases of malignant lymphoma extending through three generations wherein five sisters and their mother had histopathologically documented non-Hodgkin's lymphoma, while a granddaughter had Hodgkin's disease. An immunological study of three lymphoma survivors, nine of their first degree relatives, and four spouse controls was undertaken. Significant findings consisted of a depressed serum IgG3 level in four of the nine first-degree relatives; in two of these four, lymphocyte stimulation by both pokeweed mitogen and concanavalin A were significantly depressed. The subtle immunological abnormalities present in this kindred may be associated with the pathogenesis of the lymphomas.
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Lynch, H., Marcus, J., Weisenburger, D. et al. Genetic and immunopathological findings in a lymphoma family. Br J Cancer 59, 622–626 (1989). https://doi.org/10.1038/bjc.1989.126
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DOI: https://doi.org/10.1038/bjc.1989.126