Abstract
Angiogenin is a 14 kD protein, initially isolated as a tumour-cell secreted product but subsequently found to be a normal constituent of human plasma. It is a potent inducer of blood vessel formation on the chorioallantoic membrane of the chick embryo. Chemical characterization of the protein reveals a remarkable homology to the pancreatic ribonuclease family and has led to the identification of a unique ribonucleolytic activity for angiogenin. It is a particularly potent inhibitor of in vitro protein synthesis. Treatment with placental ribonuclease inhibitor abolishes the biological and enzymatic activities of angiogenin, an effect with important mechanistic, physiological and pharmacologic implications.
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Presented, by invitation, at the BACR/CRC/ICRF Symposium in 'Growth factors', London, December 1987.
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Riordan, J., Vallee, B. Human angiogenin, an organogenic protein. Br J Cancer 57, 587–590 (1988). https://doi.org/10.1038/bjc.1988.133
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DOI: https://doi.org/10.1038/bjc.1988.133