Abstract
Some environmental factors of possible aetiological importance for primary liver carcinoma (PLC) in males were analysed in a case-control study including 83 cases of hepatocellular carcinoma (HCC), 15 cases of intrahepatic cholangiocellular carcinoma (CC), 3 cases of haemangiosarcoma and 1 case of unspecified sarcoma in the liver--102 cases in total. Two matched controls were used in each case. One case with haemangiosarcoma was exposed to polyvinyl chloride. The case with unspecified soft-tissue sarcoma was exposed to phenoxy acids. A 4-fold increase in the risk of HCC was seen in alcoholics, and regular drinking gave a 3-fold increase in the risk. Exposure to organic solvents gave a 2-fold increase in the risk of HCC. No increased risk was observed for cases exposed to various other chemicals. Three cases of HCC had a previous diagnosis of porphyria acuta intermittens (PAI), versus no control. Six cases of HCC had a previous diagnosis of porphyria acuta intermittens (PAI), versus no control. Six cases with PLC had polyphyria cutanea tarda (PCT) which in 4 cases was related to alcoholism and in one case to haemochromatosis.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Rights and permissions
About this article
Cite this article
Hardell, L., Bengtsson, N., Jonsson, U. et al. Aetiological aspects on primary liver cancer with special regard to alcohol, organic solvents and acute intermittent porphyria - an epidemiological investigation. Br J Cancer 50, 389–397 (1984). https://doi.org/10.1038/bjc.1984.188
Issue Date:
DOI: https://doi.org/10.1038/bjc.1984.188
This article is cited by
-
Early detection of intrahepatic cholangiocarcinoma
Japanese Journal of Radiology (2019)
-
Pesticide exposure and liver cancer: a review
Cancer Causes & Control (2017)
-
The risk factors and diagnosis of cholangiocarcinoma
Hepatology International (2013)
-
High risk of primary liver cancer in a cohort of 179 patients with Acute Hepatic Porphyria
Journal of Inherited Metabolic Disease (2013)
-
Risk Factors for Gallbladder Cancer and Cholangiocarcinoma: Similarities, Differences and Updates
Journal of Gastrointestinal Cancer (2012)