Abstract
The mean total serum oestradiol level was found to be significantly increased in 8 patients with carcinoma of the breast when compared with 8 healthy reference subjects matched for race, sex and age. The calculated mean free oestradiol index was also higher in these patients. There were no significant differences, however, between the levels of LH, FSH, prolactin. DHEA-S, testosterone and SHGB in the 2 groups. The patients showed a significantly increased LH response to GnRH while there was no difference in the FSH response. Only 1/7 patients had a tumour devoid of steroid hormone receptors. It may be that an increased level of circulating oestradiol-17 beta is an important factor in the aetiology of hormone-dependent male breast cancer.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Rights and permissions
About this article
Cite this article
Nirmul, D., Pegoraro, R., Jialal, I. et al. The sex hormone profile of male patients with breast cancer. Br J Cancer 48, 423–427 (1983). https://doi.org/10.1038/bjc.1983.208
Issue Date:
DOI: https://doi.org/10.1038/bjc.1983.208
This article is cited by
-
Cancer du sein chez l’homme : à propos de trois observations à l’Hôpital d’instruction des armées Omar Bongo Ondimba (HIAOBO) (Gabon)
Bulletin de la Société de pathologie exotique (2015)
-
Clinicopathologic characteristics and survival of male breast cancer
International Journal of Clinical Oncology (2014)
-
Association of SULT1A1 Arg213His polymorphism with male breast cancer risk: results from a multicenter study in Italy
Breast Cancer Research and Treatment (2014)
-
Intratumoral Estrogen Concentration and Expression of Estrogen-Induced Genes in Male Breast Carcinoma: Comparison with Female Breast Carcinoma
Hormones and Cancer (2013)
-
Synchronous Bilateral Breast Carcinoma in a 50-Year-Old Man with 45,X/46,XY Mosaic Karyotype: Report of a Case
Surgery Today (2005)