Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Comparative studies of hypoxic-cell radiosensitization using artificially hypoxic skin in vivo

Abstract

The survival of epidermal cells in vivo has been used to assess potential radiosensitizers. Mouse skin was made acutely hypoxic for the irradiations, to give radioprotection by a factor of 2.7-3.0. Several concentrations of each drug were used to determine whether any of them were more effective sensitizers than misonidazole. The SER at each concentration was determined from radiobiological dose-response curves. The blood concentration and toxicity of the compounds were also determined. The sensitizing efficiency, assessed in several ways, indicated that only Ro 03-8799 gave significantly greater sensitization than misonidazole, and then only when assessed by comparing the compounds on the basis of equimolar blood concentrations. If the comparison of efficiency was made in terms of LD50 the ranking order change. The need for a more clinically relevant test of peripheral neurotoxicity is stressed.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Denekamp, J., Michael, B., Minchinton, A. et al. Comparative studies of hypoxic-cell radiosensitization using artificially hypoxic skin in vivo. Br J Cancer 45, 247–255 (1982). https://doi.org/10.1038/bjc.1982.40

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/bjc.1982.40

Search

Quick links