Abstract
Radiolabelled affinity-purified antibody to carcinoembryonic antigen (CEA) was injected i.v. into immune-suppressed mice carrying xenografts of human breast carcinoma. Its distribution in the tumours was examined by a combination of immunocytochemistry and autoradiography. The antibody interacted predominantly with the CEA in the extracellular tumour space, rather than on the cell membrane or cytoplasm.
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Moshakis, V., Ormerod, M., Westwood, J. et al. The site of binding of anti-CEA antibodies to tumour CEA in vivo: an immunocytochemical and autoradiographic approach. Br J Cancer 46, 18–21 (1982). https://doi.org/10.1038/bjc.1982.159
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DOI: https://doi.org/10.1038/bjc.1982.159
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