Abstract
The in vitro chemosensitivity of primary monolayer cultures of human ovarian tumours to a wide range of chemotherapeutic agents has been determined using 3H-leucine incorporation as an index of cytotoxicity. Of 67 specimens received, 35 have been successfully cultured and tested for chemosensitivity. Drugs tested included alkylating agents, antibiotics, antimitotics, antimetabolites and progestogens. The overall incidence of efficacy of the drugs corresponded with the incidence which might be expected from data on the clinical response rates produced by the various drugs. Cultures from the tumour cells of treated patients generally showed greater resistance than tumours of untreated patients. Correlation between in vitro results and in vivo response was positive in all 8 patients receiving first-line chemotherapy and in 57% (4/7) patients receiving second-line chemotherapy.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Rights and permissions
About this article
Cite this article
Wilson, A., Neal, F. In vitro sensitivity of human ovarian tumours to chemotherapeutic agents. Br J Cancer 44, 189–200 (1981). https://doi.org/10.1038/bjc.1981.170
Issue Date:
DOI: https://doi.org/10.1038/bjc.1981.170
This article is cited by
-
Antitumor activity of treosulfan against human breast carcinomas
Cancer Chemotherapy and Pharmacology (1992)
-
Activity of 2-fluoro-Ara AMP against gynecologic tumors in the soft agar assay
Investigational New Drugs (1986)
-
The human tumor colony-forming chemosensitivity assay: A biological and clinical review
Investigational New Drugs (1984)