Abstract
The surviving fraction (SF) of Chinese hamster cells and HeLa cells after treatment with a range of Adriamycin concentrations and exposure times was determined. The cytostatic effect was proportional to the product of extracellular drug concentration (c) and exposure time (t) according to the equation: sf=e-ktc. By determining the intracellular drug concentration at various exposures, it could be shown that absorbed dose is not proportional to exposure dose.
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Eichholtz-Wirth, H. Dependence of the cytostatic effect of adriamycin on drug concentration and exposure time in vitro. Br J Cancer 41, 886–891 (1980). https://doi.org/10.1038/bjc.1980.165
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DOI: https://doi.org/10.1038/bjc.1980.165
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