Abstract
The i.v. administration of Corynebacterium parvum (CP) to patients who had recently undergone resection of colorectal tumours was found to have the following effects: 1. Polymorphonuclear leucocyte counts were raised 24 h after CP administration, while both lymphocyte and monocyte counts fell during this period. Polymorph and lymphocyte counts had returned to pre-infusion levels at one week, but monocyte counts were significantly increased at this time. 2. The lymphocyte mitotic response to PHA was reduced during the 24 h after CP infusion. 3 The spontaneous, antibody-induced, and PHA-induced lymphocyte-mediated cytotoxicity against a nucleated target cell fell significantly 3 h after CP infusion, but these functions recovered by 7 days. 4. A rise in serum lysozyme was found 3 and 24 h after CP administration. However, these increased levels were not maintained beyond 24 h.
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Gill, P., Waller, C., MacClennan, I. et al. Effect of intravenous corynebacterium parvum on peripheral-blood effector cells of cancer patients. Br J Cancer 41, 782–789 (1980). https://doi.org/10.1038/bjc.1980.142
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DOI: https://doi.org/10.1038/bjc.1980.142