Abstract
Diethylnitrosamine (DENA) at 10 mg/kg was fed to adult rats either continuously or for periods ranging from 1 to 10 weeks. Survival correlated inversely with the duration of carcinogen feeding. Less than 4 weeks of DENA feeding produced only preneoplastic foci that persisted indefinitely, 4 weeks were found to be necessary for the transformation of preneoplastic lesions into liver cancers, after 6 weeks, the incidence of hepatomas was 100%. The process of liver cancerization appeared to be identical whether DENA was fed for 8 weeks or continuously up to the time of death. These results are discussed in the light of the evolution of the homoeostatic control of liver-cell division during DENA feeding, in order to distinguish the different successive roles played by the carcinogen.
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Barbason, H., Smoliar, V., Fridman-Manduzio, A. et al. Effects of discontinuation of chronic feeding of diethylnitrosamine on the development of hepatomas in adult rats. Br J Cancer 40, 260–267 (1979). https://doi.org/10.1038/bjc.1979.174
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DOI: https://doi.org/10.1038/bjc.1979.174