Abstract
Whole body X-irradiation (400 rad) of C57BL mice, either before or after i.m. implantation of the syngeneic fibrosarcoma, FS6, influenced both the growth of the tumours and their cellular composition, particularly their macrophage content. Pre-irradiation resulted in slower initial growth of tumours, and a concomitant lack of host-cell infiltration, but when tumours began to grow at a rate parallel to controls infiltration by host cells was demonstrable. Similarly, irradiation of the tumour-bearing host resulted in a temporary cessation of growth, and a decrease in the macrophage content, which did not return to control levels for 2-3 weeks after irradiation. The significance of these results is discussed in relation to the possibility that infiltrating host cells, particularly macrophages, may stimulate the growth of this tumour.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Rights and permissions
About this article
Cite this article
Evans, R. Effect of X-irradiation on host-cell infiltration and growth of a murine fibrosarcoma. Br J Cancer 35, 557–566 (1977). https://doi.org/10.1038/bjc.1977.89
Issue Date:
DOI: https://doi.org/10.1038/bjc.1977.89
This article is cited by
-
Microglial activation state exerts a biphasic influence on brain endothelial cell proliferation by regulating the balance of TNF and TGF-β1
Journal of Neuroinflammation (2010)
-
Macrophages and tumor angiogenesis
Leukemia (2007)
-
Influence of growth environment on the ganglioside composition of an experimental mouse brain tumor
Molecular and chemical neuropathology (1994)
-
Evasion of host defences by tumours
Immunology & Cell Biology (1987)
-
In vitro interactions of murine peritoneal macrophages and sarcoma cells
Virchows Archiv B Cell Pathology Including Molecular Pathology (1986)