Abstract
Two proprietary semi-permanent hair dyes were tested for carcinogenicity in A and DBAf mice by repeated topical applications in aqueous acetone. Mice of both strains developed lymphoid tumours but experimental differences were marked only in DBAf mice. A number of tumours of the ovary and uterus, and some skin papillomas near the penis, occured in dye-treated but not in control DBAf mice. As many hair-dye constituents are known mutagens, adequate carcinogenicity testing of these substances, and epidemiological study of exposed human populations, are needed for evaluating possible health hazard from hair dyeing.
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Searle, C., Jones, E. Effects of repeated applications of two semi-permanent hair dyes to the skin of A and DBAf mice. Br J Cancer 36, 467–478 (1977). https://doi.org/10.1038/bjc.1977.216
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DOI: https://doi.org/10.1038/bjc.1977.216
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