A combination of chlorambucil, vinblastine, procarbazine and prednisolone for treatment of Hodgkin's disease

Abstract

Seventy patients with Hodgkin's disease have been treated with a combination of chlorambucil, vinblastine, procarbazine and prednisolone (Ch1VPP). The complete remission rate of 75-7% compares well with that produced by other combinations. The combination is non-toxic, easily administered and can be given safely to outpatients. Its main advantage is that it is far less upsetting to patients than combinations containing nitrogen mustard.

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McElwain, T., Toy, J., Smith, E. et al. A combination of chlorambucil, vinblastine, procarbazine and prednisolone for treatment of Hodgkin's disease. Br J Cancer 36, 276–280 (1977). https://doi.org/10.1038/bjc.1977.187

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