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Structure-activity relationships in nitrosamine carcinogenesis

British Journal of Cancer volume 33, pages 307–311 (1976)Cite this article

Abstract

Statistically significant correlations have been demonstrated between carcinogenic activity, toxicity and number of carbons per molecule for an extensive set of nitrosamines. Such correlations, involving only bulk molecular properties indicate that the chemical nature of the alkyl substituents need not be the sole determinants of carcinogenic activity. These structure-activity relationships can be used to estimate carcinogenic activity with some degree of confidence.

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Authors
  1. J S Wishnok
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  2. M C Archer
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Wishnok, J., Archer, M. Structure-activity relationships in nitrosamine carcinogenesis. Br J Cancer 33, 307–311 (1976). https://doi.org/10.1038/bjc.1976.44

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  • DOI: https://doi.org/10.1038/bjc.1976.44

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