Abstract
The immunoprophylactic effects of the methanol extraction residue (MER) of BCG were investigated in Strain 2 guinea-pigs injected with cells of the transplantable, diethylnitrosamine-induced, Line 10 hepatocarcinoma. Pretreatment with MER at times ranging from 18 to 182 days prior to tumour implantation protected approximately 40% of guinea-pigs from progressive neoplastic disease. In addition, MER-treated animals developed specific cell-mediated anti-tumour immunity both more rapidly and at higher levels than did non-MER-treated tumour-bearing controls. It was not possible, however, to prognosticate from the results of such laboratory studies to the outcome of immunoprophylaxis.
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Wainberg, M., Deutsch, V. & Weiss, D. Stimulation of anti-tumour immunity in guinea-pigs by methanol extraction residue of BCG. Br J Cancer 34, 500–508 (1976). https://doi.org/10.1038/bjc.1976.204
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DOI: https://doi.org/10.1038/bjc.1976.204
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