Abstract
A recently introduced assay of cell mediated immunity and humoral inhibitory factors has been evaluated in colorectal cancer patients. Using a perchloric acid extract of adenocarcinoma of the large bowel as antigen, 16/27 patients with colorectal cancer had significant cellular reactivity when their separated peripheral leucocytes were tested in homologous AB serum. In autologous serum only 7/27 had significant reactivity, 6/20 patients with a variety of other malignancies showed sensitization to the colorectal antigen preparation. It is concluded that the leucocyte adherence inhibiton test may offer a simple method of assaying for serum blocking factors in sequential studies but will be of little value in the diagnosis of large bowel cancer.
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Armitstead, P., Gowland, G. The leucocyte adherence inhibtion test in cancer of the large bowel. Br J Cancer 32, 568–573 (1975). https://doi.org/10.1038/bjc.1975.262
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DOI: https://doi.org/10.1038/bjc.1975.262
