Abstract
The leucocyte migration and guinea-pig macrophage migration procedures were used to assess cell mediated, tumour directed immune reactions in patients with mammary carcinoma undergoing simple mastectomy with or without post-operative irradiation. Forty-seven per cent of patients reacted to autologous tumour antigens and 40% to allogeneic antigens when tested 7 days after operation; 23% reacted to autologous antigens at 2 months, 19% at 6 months and 34% at 1 year after surgery. Reactions to benign tissue fractions were rare. Better discrimination between test and control subjects was obtained when 3000 g sediments rather than nuclei-depleted homogenates (extracts) were used. Irradiation 3-7 weeks post-operatively did not depress the in vitro response at 2 months and yielded a higher rate of positive reactions at 6 months. Correlations of serial LMT responses with certain clinical findings are discussed.
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Jones, B., Turnbull, A. Horizontal studies of cell mediated immune reactions to autologous tumour antigens in patients with operable mammary carcinoma. Br J Cancer 32, 339–344 (1975). https://doi.org/10.1038/bjc.1975.232
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DOI: https://doi.org/10.1038/bjc.1975.232