Abstract
The effects of aflatoxin B1 on the endoplasmic reticulum of rat liver has been examined in vivo. Electron microscopy has shown a disorganization and degranulation of rough surfaced membrane under these conditions and evidence is presented that this is a primary effect of the toxin, and results from the direct attack of the aflatoxin on the steroid-dependent ribosome binding sites on the membrane. A technique is described by which the presence of degranulated rough membrane may be detected in microsomal preparations.
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Williams, D., Clark, R. & Rabin, B. The Effects of Aflatoxin B1 in vivo on Membrane—Ribosome Association. Br J Cancer 27, 283–290 (1973). https://doi.org/10.1038/bjc.1973.35
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DOI: https://doi.org/10.1038/bjc.1973.35
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