Abstract
Immunoglobulin levels (IgA, IgG, IgM) have been estimated in protein extracts of 55 malignant and 20 benign tumours of the breast, and in 17 normal tissues from a cancer bearing breast. IgA and IgG were significantly reduced in cancer compared with both benign and normal tissues but IgM, detected in only a third of tumours, was significantly increased. Total immunoglobulin levels and IgG in the malignant tumours correlated with plasma cell infiltration.
The menstrual status of the patient had no influence on these findings.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Rights and permissions
About this article
Cite this article
Roberts, M., Bass, E., Wallace, I. et al. Local Immunoglobulin Production in Breast Cancer. Br J Cancer 27, 269–275 (1973). https://doi.org/10.1038/bjc.1973.33
Issue Date:
DOI: https://doi.org/10.1038/bjc.1973.33
This article is cited by
-
2D immunoblots show differential response of mouse IgG and IgM antibodies to antigens of mammary carcinoma 4Â T1 cells
Cancer Cell International (2014)
-
Class distribution of immunoglobulin-containing plasma cells in the stroma of medullary carcinoma of breast
Breast Cancer Research and Treatment (1986)