Abstract
The interconversion of tritium labelled oestrone and oestradiol-17β has been investigated in human breast tumours maintained in organ culture for 3 days. Benign tumours were significantly different from scirrhous carcinomata both in the concentration of radioactivity taken up by the tissue and in the ratios of oestradiol-17β/oestrone achieved. The fact that malignant tumours were able to convert oestrone to oestradiol-17β is of interest in view of the relatively high plasma levels of oestrone in post-menopausal women.
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Willcox, P., Thomas, G. Oestrogen Metabolism in Cultured Human Breast Tumours. Br J Cancer 26, 453–460 (1972). https://doi.org/10.1038/bjc.1972.62
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DOI: https://doi.org/10.1038/bjc.1972.62
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