Abstract
A microradioimmunoassay technique is described for detecting carcinoembryonic antigen (CEA) in whole serum. It differs from previous methods in being performed on 0ยท025 ml of whole serum instead of 5 ml of serum extracted with perchloric acid. The present assay was sufficiently sensitive to detect 85% of carcinomata, localized to the colon, but positive results occurred also with certain non-gastrointestinal cancers, chiefly lung and breast, and certain non-malignant diseases. Many of the latter sera, with the general exception of alcoholic cirrhosis and pancreatitis, gave negative results after extraction with perchloric acid. It is suggested that a direct assay for CEA in whole serum may permit testing of large numbers of sera by laboratories with facilities for radioimmunoassays.
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MacSween, J., Warner, N., Bankhurst, A. et al. Carcinoembryonic Antigen in Whole Serum. Br J Cancer 26, 356โ360 (1972). https://doi.org/10.1038/bjc.1972.46
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DOI: https://doi.org/10.1038/bjc.1972.46
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