Abstract
Fifty-three biopsies from the oral mucosa in 51 Indian villagers with oral submucous fibrosis have been studied for epithelial changes. A marked atrophy of the epithelium was found in 71.7%; the atrophic epithelium showed no rete ridges. The normally unkeratinized buccal mucosa revealed either ortho- or parakeratosis or hyperortho- or hyperparakeratosis in 48.0%. In one patient the histologic examination disclosed a squamous cell carcinoma. In 22.6% an epithelial atypia was found. The histologic features in these atypias are compared with those seen in leukoplakias from the same survey. The possible precancerous nature of submucous fibrosis is discussed.
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Pindborg, J., Mehta, F. & Daftary, D. Occurrence of Epithelial Atypia in 51 Indian Villagers with Oral Submucous Fibrosis. Br J Cancer 24, 253–257 (1970). https://doi.org/10.1038/bjc.1970.28
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DOI: https://doi.org/10.1038/bjc.1970.28
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