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Papas A, He T et al. J Periodontol 2007; 78: 1505–1314

Triclosan in a copolymer dentifrice formulation has been shown to be helpful in slowing periodontitis progression. Fluoride has been shown to reduce root caries, and has some antimicrobial effects. This study compared fluoride and fluoride/triclosan dentifrices in a double-masked RCT with 440 patients with medication-related xerostomia, of whom 392 completed 4 evaluable visits.

Over an initial 1-yr run-in phase, subjects lost a mean of 1.3 mm clinical attachment, and during the subsequent 2 yrs they regained about 0.8 mm. During the 2 years about ¼ of root caries sites appeared to remineralise. There were no significant differences between groups in periodontal or caries data.