Circulating biomarkers for cardiovascular diseases: the beats never stop

Cardiovascular diseases (CVD) remain a major health issue and a grave socio-economic burden, being the No. 1 killer in major industrial countries and the main reason for frequent re-hospitalization1. In recent years, unmet needs for a distinct cardiovascular risk assessment allowing for standardized guidelines on personalized therapy have led to an intensive research on biomarkers. Even in this post-cTn (cardiac troponin) and post-BNP (B-type natriuretic peptide) era, there are still significant gaps and huge demands for more reliable and innovative methods and tools for diagnosis and evidence-guided management of CVD. Under this context, the basic research and clinical use of biomarkers have gained a tremendous momentum in the past decade. The use of single or multiple biomarkers as reliable and reproducible indicatives of the risk, severity, and progression stage of CVD greatly enhances the diagnostic decision and prognostic ability of emergency department physicians, cardiologists, and cardiovascular surgeons in their routine patient care duties. The prudential utilization of valid biomarkers in clinical practice can reduce time and costs for an accurate diagnosis and proper personalized therapy of CVD patients. As suggested in Figure 1, biomarker testing may play a central role in the evidence-based Cardiovascular Medicine and it can in turn promote the improved clinical outcome, better quality of life, and alleviated socio-economic burden of CVD.

Figure 1
figure1

A graphical notion suggesting biomarker testing may play a central role in improvement of cardiovascular risk assessment and reduced time and cost for an accurate diagnosis and personalized medicine that can eventually lead to improved clinical outcome, better quality of life, and alleviated socio-economic burden of cardiovascular diseases.

Accordingly, this Special Issue of Acta Pharmacologica Sinica was planned to provide a forum for high quality original research and review articles to showcase the most recent advances in translational research and clinical practices on a wide-spectrum array of conventional as well as novel cardiovascular biomarkers. Coverage of this Special Issue encompasses various forms of large or small molecules, such as proteins, peptides, cytokines, microRNAs, and metabolic by-products that are released from injured cardiovascular tissues into blood stream during various CVD events.

A total of 18 papers authored by 108 scientists from 15 countries, i.e. Australia, Austria, China, Czech Republic, Germany, Greece, Hong Kong (China), Malaysia, Poland, Portugal, Romania, Slovak Republic, Switzerland, United Kingdom, and United States, are accepted and represent a truly global effort for tackling the unsolved issues and new discoveries of CVD biomarkers. These collective efforts have also made the current Special Issue probably the most “international” volume of Acta Pharmacologica Sinica in the Journal's 30+-year history.

This Special Issue covers a variety of pathological types of CVD, including acute myocardial infarction (AMI)2,3,4,5, heart failure6, aortic aneurysms7;8, carotid restenosis9, pulmonary arterial hypertension (PAH)10, and cardiac amyloidosis11. Several review articles provided in-depth analyses on the important diagnostic and prognostic roles of zinc12, oxylipins13, and leptin14 in the fundamental cellular signaling and pathogenic processes in CVD and diabetes. Notably, all the 7 original research articles are clinical research on Asian patients with AMI5 or PAH10 as well as European patients with AMI2, chronic heart failure6, vascular aneurysm7 or restenosis9, and stroke15.

It is noteworthy that 4 review articles4,16,17,18 and 2 original research papers2,10in this Special Issue are focusing on a cutting-edged topic concerning the potential roles of circulating noncoding RNAs (ncRNAs), which include microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs), in serving as a new generation of biomarkers for CVD. Among these elegant works, Bayoumi et al. reviewed the circular noncoding RNAs as potential therapies and circulating biomarkers for CVD18. The similar topic was also thoroughly analyzed by Zhou et al17 and Stepien et al16, who provided their own perspectives. Two other papers by Wang et al4 and Song et al10 provided more focused discussions respectively on the use of microRNAs for early detection of CVD such as AMI4 and pulmonary hypertension10. We wish this panel of 6 articles may help the readers to gain a comprehensive grasp on the upcoming trend of using miRNAs, lncRNAs, and circRNAs as the newest class of CVD biomarkers that will be eventually utilized in the clinical settings considering the above-discussed keen interests and intensive investigations in this research area.

Another highlighted area of discussion in this Special Issue is on the technological and methodological innovations for the CVD biomarker detection. Our invited experts have communicated their original research results using various technologies from advanced chip-based digital PCR2 to 2D-gel analysis5. They also thoroughly reasoned the needs for multiplex approach to enhance diagnostic accuracy superior to the single biomarker detection19.

In brief, we believe that these collective efforts will be instrumental for future research and technological development of new CVD biomarkers that can be used for saving lives and improving clinical outcomes in tens of millions CVD patients worldwide. For these meaningful endeavor and noble cause, we would like to most sincerely thank all of our participating authors and numerous contributing expert reviewers, as well as the Editor-in-Chief (Dr Jian DING), Editorial Manager (Ms. Min-shu WU), Executive Editor (Ms. Qian-rong ZHU), and Handling Editor (Dr Bin-jia ZHANG) and other journal staff for their extraordinary efforts and supports that jointly made this extensive publication endeavor possible.

References

  1. 1

    Roth GA, Johnson C, Abajobir A, Abd-Allah F, Abera SF, Abyu G, et al. Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015. J Am Coll Cardiol 2017; 70: 1–25.

  2. 2

    Robinson S, Follo M, Haenel D, Mauler M, Stallmann D, Heger LA, et al. Chip-based digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction patients. Acta Pharmacol Sin 2018; 39: 1217–27.

    Article  Google Scholar 

  3. 3

    Ye XD, He Y, Wang S, Wong GT, Irwin MG, Xia Z. Heart-type fatty acid binding protein (H-FABP) as a biomarker for acute myocardial injury and long-term post-ischemic prognosis. Acta Pharmacol Sin 2018; 39: 1155–63.

    CAS  Article  Google Scholar 

  4. 4

    Wang C, Jing Q. Non-coding RNAs as biomarkers for acute myocardial infarction. Acta Pharmacol Sin 2018; 39: 1110–9.

    Article  Google Scholar 

  5. 5

    Rahim MAA, Rahim ZHA, Ahmad WAW, Bakri MM, Ismail MD, Hashim OH. Inverse changes in plasma tetranectin and titin levels in patients with type 2 diabetes mellitus: a potential predictor of acute myocardial infarction? Acta Pharmacol Sin 2018; 39: 1197–207.

    Article  Google Scholar 

  6. 6

    Jirak P, Fejzic D, Paar V, Wernly B, Pistulli R, Rohm I, et al. Influences of Ivabradine treatment on serum levels of cardiac biomarkers sST2, GDF-15, suPAR and H-FABP in patients with chronic heart failure. Acta Pharmacol Sin 2018; 39: 1189–96.

    Article  Google Scholar 

  7. 7

    Papoutsis K, Kapelouzou A, Tsilimigras DI, Patelis N, Kouvelos G, Schizas D, et al. Associations between serum relaxin 2, aneurysm formation/size and severity of atherosclerosis: a preliminary prospective analysis. Acta Pharmacol Sin 2018; 39: 1243–8.

    CAS  Article  Google Scholar 

  8. 8

    Tsilimigras DI, Sigala F, Karaolanis G, Ntanasis-Stathopoulos I, Spartalis E, Spartalis M, et al. Cytokines as biomarkers of inflammatory response after open versus endovascular repair of abdominal aortic aneurysms: a systematic review. Acta Pharmacol Sin 2018; 39: 1164–75.

    CAS  Article  Google Scholar 

  9. 9

    Maskanakis A, Patelis N, Karaolanis G, Davakis S, Schizas D, Perrea D, et al. Apolipoprotein J as a predictive biomarker for restenosis after carotid endarterectomy: a retrospective study. Acta Pharmacol Sin 2018; 39: 1237–42.

    CAS  Article  Google Scholar 

  10. 10

    Song XW, Zou LL, Cui L, Li SH, Qin YW, Zhao XX, et al. Plasma miR-451 with echocardiography serves as a diagnostic reference for pulmonary hypertension. Acta Pharmacol Sin 2018; 39: 1208–16.

    CAS  Article  Google Scholar 

  11. 11

    Luciani M, Troncone L, del Monte F. Current and future circulating biomarkers for cardiac amyloidosis. Acta Pharmacol Sin 2018; 39: 1133–41.

    CAS  Article  Google Scholar 

  12. 12

    Choi S, Liu X, Pan Z. Zinc deficiency and cellular oxidative stress: prognostic implications in cardiovascular diseases. Acta Pharmacol Sin 2018; 39: 1120–32.

    CAS  Article  Google Scholar 

  13. 13

    Nayeem MA. Role of oxylipins in cardiovascular diseases. Acta Pharmacol Sin 2018; 39: 1142–54.

    CAS  Article  Google Scholar 

  14. 14

    Katsiki N, Mikhailidis DP, Banach M. Leptin, cardiovascular diseases and type 2 diabetes mellitus. Acta Pharmacol Sin 2018; 39: 1176–88.

    CAS  Article  Google Scholar 

  15. 15

    Hutanu A, Iancu M, Balasa R, Maier S, Dobreanu M. Predicting functional outcome of ischemic stroke patients in Romania based on plasma CRP, sTNFR-1, D-Dimers, NGAL and NSE measured using a biochip array. Acta Pharmacol Sin 2018; 39: 1228–36.

    CAS  Article  Google Scholar 

  16. 16

    Stepien E, Costa MC, Kurc S, Drozdz A, Cortez-Dias N, Enguita FJ. The circulating non-coding RNA landscape for biomarker research: lessons and prospects from cardiovascular diseases. Acta Pharmacol Sin 2018; 39: 1085–99.

    CAS  Article  Google Scholar 

  17. 17

    Zhou SS, Jin JP, Wang JQ, Zhang ZG, Freedman JH, Zheng Y, et al. miRNAs in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges. Acta Pharmacol Sin 2018; 39: 1073–84.

    CAS  Article  Google Scholar 

  18. 18

    Bayoumi AS, Aonuma T, Teoh JP, Tang YL, Kim IM. Circular noncoding RNAs as potential therapies and circulating biomarkers for cardiovascular diseases. Acta Pharmacol Sin 2018; 39: 1100–9.

    CAS  Article  Google Scholar 

  19. 19

    Adamcova M, Simko F. Multiplex biomarker approach to cardiovascular diseases. Acta Pharmacol Sin 2018; 39: 1068–72.

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding authors

Correspondence to Lei Xi or George Kouvelos or Nazareno Paolocci.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Xi, L., Kouvelos, G. & Paolocci, N. Circulating biomarkers for cardiovascular diseases: the beats never stop. Acta Pharmacol Sin 39, 1065–1067 (2018). https://doi.org/10.1038/aps.2018.43

Download citation

Further reading

Search

Quick links