Sulforaphane (SF) is a phytochemical that displays both anticarcinogenic and anticancer activity. SF modulates many cancer-related events, including susceptibility to carcinogens, cell death, cell cycle, angiogenesis, invasion and metastasis. We review its discovery and development as a cancer chemopreventive agent with the intention of encouraging further research on this important compound and facilitating the identification and development of new phytochemicals for cancer prevention.
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Studies carried out in the authors' laboratory were supported in part by US Public Service Grants CA80962 and CA100623.
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Zhang, Y., Tang, L. Discovery and development of sulforaphane as a cancer chemopreventive phytochemical. Acta Pharmacol Sin 28, 1343–1354 (2007). https://doi.org/10.1111/j.1745-7254.2007.00679.x
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