Abstract
Aim:
To study effects of hydrogen sulfide (H2S) on the carotid sinus baroreflex (CSB).
Methods:
The functional curve of the carotid sinus baroreflex was measured by recording changes in arterial pressure in anesthetized male rats with perfused carotid sinus.
Results:
H2S (derived from sodium hydrosulfide) at concentrations of 25, 50, and 100 μmol/L facilitated the CSB, shifting the functional curve of the baroreflex downward and to the left. There was a marked increase in peak slope (PS) and reflex decrease in blood pressure (RD). Effects were concentration-dependent. Pretreatment with glibenclamide (20 μmol/L), a KATP channel blocker, abolished the above effects of H2S on CSB. Pretreatment with Bay K8644 (an agonist of calcium channels; 500 μmol/L) eliminated the effect of H2S on CSB. An inhibitor of cystathionine γ-lyase (CSE), DL-propargylglycine (PPG; 200 μmol/L), inhibited CSB in male rats and shifted the functional curve of the baroreflex upward and to the right.
Conclusion:
These data suggest that exogenous H2S exerts a facilitatory role on isolated CSB through opening KATP channels and further closing the calcium channels in vascular smooth muscle. Endogenous H2S may activate the activity of the CSB in vivo.
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Xiao, L., Wu, Ym., Zhang, H. et al. Hydrogen sulfide facilitates carotid sinus baroreflex in anesthetized rats. Acta Pharmacol Sin 27, 294–298 (2006). https://doi.org/10.1111/j.1745-7254.2006.00269.x
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DOI: https://doi.org/10.1111/j.1745-7254.2006.00269.x
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