Abstract
Aim:
To investigate the role of histamine in memory deficits induced by MK-801 infusion into the ventral hippocampus in rats.
Methods:
An 8-arm radial maze (4 arms baited) was used to assess spatial memory.
Results:
Bilateral ventral intrahippocampal (ih) infusion of MK-801 (0.3 μg/site), an N-methyl-D-aspartate (NMDA) antagonist, impaired the retrieval process in both working memory and reference memory. Intrahippocampal injection of histamine (25 or 50 ng/site) or intraperitoneal (ip) injection of histidine (25, 50 or 100 mg/kg) markedly ameliorated the spatial memory deficits induced by MK-801. Both the histamine H1 antagonist pyrilamine (0.5 or 1.0 μg/site, ih) and the H2 antagonist cimetidine (2.5 μg/site, ih) abolished the ameliorating effect of histidine (100 mg/kg, ip) on reference memory deficits, but not that on working memory deficits induced by MK-801.
Conclusion:
The results indicate that histamine in the ventral hippocampus can ameliorate MK-801-induced spatial memory deficits, and that histamine's effect on reference memory is mediated by postsynaptic histamine H1 and H2 receptors.
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References
Nadel L . Dorsal and ventral hippocampal lesions and behavior. Physiol Behav 1968; 3: 891–900.
Petrovich GD, Canteras NS, Swanson LW . Combinatorial amygdalar inputs to hippocampal domains and hypothalamic behavior systems. Brain Res Brain Res Rev 2001; 38: 247–89.
Andersen P, Bliss TV, Skrede KK . Lamellar organization of hippocampal pathways. Exp Brain Res 1971; 13: 222–38.
Bannerman DM, Yee BK, Good MA, Heupel MJ, Iversen SD, Rawlins JN . Double dissociation of function within the hippocampus: a comparison of dorsal, ventral, and complete hippocampal cytotoxic lesions. Behav Neurosci 1999; 113: 1170–88.
Moser E, Moser MB, Andersen P . Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions. J Neurosci 1993; 13: 3916–25.
Moser MB, Moser EI . Distributed encoding and retrieval of spatial memory in the hippocampus. J Neurosci 1998; 18: 7535–42.
Bannerman DM, Grubb M, Deacon RM, Yee BK, Feldon J, Rawlins JN . Ventral hippocampal lesions affect anxiety but not spatial learning. Behav Brain Res 2003; 139: 197–213.
Kjelstrup KG, Tuvnes FA, Steffenach HA, Murison R, Moser EI, Moser MB . Reduced fear expression after lesions of the ventral hippocampus. Proc Natl Acad Sci USA 2002; 99: 10825–30.
Ferbinteanu J, Ray C, McDonald RJ . Both dorsal and ventral hippocampus contribute to spatial learning in Long-Evans rats. Neurosci Lett 2003; 345: 131–5.
Chen, Z . Effect of histamine H3–receptor antagonist clobenpropit on spatial memory of radial maze performance in rats. Acta Pharmacol Sin 2000; 21: 905–10.
Chen Z, Kamei C . Facilitating effects of histamine on spatial memory deficit induced by scopolamine in rats. Acta Pharmacol Sin 2000; 21: 814–8.
Kamei C, Chen Z, Nakamura S, Sugimoto Y . Effects of intracerebroventricular injection of histamine on memory deficits induced by hippocampal lesions in rats. Methods Find Exp Clin Pharmacol 1997; 19: 253–9.
Chen Z, Sugimoto Y, Kamei C . Effects of intracerebroventricular injection of α-fluoromethylhistidine on radial maze performance in rats. Pharmacol Biochem Behav 1999; 64: 513–8.
Chen Z, Zhao Q, Sugimoto Y, Fujii Y, Kamei C . Effects of histamine on MK-801-induced memory deficits in radial maze performance in rats. Brain Res 1999; 839: 186–9.
Bekkers JM . Enhancement by histamine of NMDA-mediated synaptic transmission in the hippocampus. Science 1993; 261: 104–6.
Pitkanen M, Sirvio J, MacDonald E, Niemi S, Ekonsalo T, Riekkinen, P Sr . The effects of D-cycloserine and MK-801 on the performance of rats in two spatial learning and memory tasks. Eur Neuropharmacol 1995; 5: 457–63.
Vorobjev VS, Sharonova IN, Walsh IB, Haas HL . Histamine potentiates N-methyl-D-aspartate responses in acutely isolated hippocampal neurons. Neuron 1993; 11: 837–44.
Huang YW, Chen Z, Hu WW, Zhang LS, Wu W, Ying LY, et al. Facilitating effect of histamine on spatial memory deficits induced by dizocilpine as evaluated by 8-arm radial maze in SD rats. Acta Pharmacol Sin 2003; 24: 1270–6.
Huang YW, Hu WW, Chen Z, Zhang LS, Shen HQ, Timmerman H, et al. Effect of the histamine H3-antagonist clobenpropit on spatial memory deficits induced by MK–801 as evaluated by radial maze in Sprague-Dawley rats. Behav Brain Res 2004; 151: 287–93.
Poucet B, Herrmann T, Buhot MC . Effects of short-lasting inactivations of the ventral hippocampus and medial septum on long-term and short-term acquisition of spatial information in rats. Behav Brain Res 1991; 44: 53–65.
Passani MB, Bacciottini LB, Mannaioni PF, Blandina P . Central histaminergic system and cognition. Neurosci Biobehav Rev 2000; 24: 107–13.
Kamei C, Chung YH, Tasaka K . Influence of certain H1-blockers on the step-through active avoidance response in rats. Psychopharmacology (Berlin) 1990; 102: 312–8.
Flood JF, Uezu K, Morley JE . Effect of histamine H2 and H3 receptor modulation in the septum on post-training memory processing. Psychopharmacology (Berlin) 1998; 140: 279–84.
Giovannini MG, Efoudebe M, Passani MB, Baldi E, Bucherelli C, Giachi F, et al. Improvement in fear memory by histamine-elicited ERK2 activation in hippocampal CA3 cells. J Neurosci 2003; 23: 9016–23.
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Project supported by the National Natural Science Foundation of China (No 30000019, 30371638, 30472013) and the Zhejiang Provincial Natural Science Foundation of China (No R303779).
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Xu, Ls., Yang, Lx., Hu, Ww. et al. Histamine ameliorates spatial memory deficits induced by MK-801 infusion into ventral hippocampus as evaluated by radial maze task in rats. Acta Pharmacol Sin 26, 1448–1453 (2005). https://doi.org/10.1111/j.1745-7254.2005.00229.x
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DOI: https://doi.org/10.1111/j.1745-7254.2005.00229.x
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