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Exposure to phthalate esters from indoor environment

Abstract

Phthalate esters and phosphate esters in samples of indoor air from 27 houses in the Tokyo Metropolitan area were quantified using gas chromatograph/mass spectrometer and gas chromatograph/flame photometric detector after adsorption on to charcoal and solvent extraction. The median concentrations of diethyl phthalate, dibutyl phthalate (DBP), butylbenzyl phthalate, dicyclohexyl phthalate and diethylhexyl phthalate were 0.10, 0.39, 0.01, 0.07 and 0.11 μg/m3, respectively. The median concentrations of tributyl phosphate, tris(2-chloroethyl) phosphate, triphenyl phosphate and tris(2-butoxyethyl) phosphate were less than 0.001 μg/m3. DBP was detected at the highest concentration (6.18 μg/m3) in a new residential housing. This research indicated that exposure to phthalate esters through inhalation of air from the indoor environment is as important as dietary intake of phthalate esters, and can contribute to daily intake to a much greater extent than has been assumed hitherto.

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References

  • Environmental Agency of Japan. The Survey Data of the Levels of Endocrine Disrupting Chemicals in Atmosphere. Environmental Agency of Japan, Tokyo, 1999.

  • Foster P.M.D., Cattley R.C., and Mylchreest E. Effects of di-n-butyl phthalate (DBP) on male reproductive development in the rat: implications for human risk assessment. Food Chem Toxicol 2000: 38: S97–S99.

    CAS  Article  Google Scholar 

  • Harris C.A., Henttu P., Parker M.G., and Sumpter J.P. The estrogenic activity of phthalate esters in vitro. Environ Health Perspect 1997: 105: 802–811.

    CAS  Article  Google Scholar 

  • Hoff R.M., and Chan K.-W. Measurement of polycyclic aromatic hydrocarbons in the air along the Niagara River. Environ Sci Technol 1987: 21: 556–561.

    CAS  Article  Google Scholar 

  • International Commission on Radiological Protection. Report of the Task Group on Reference Man, ICRP Publication No. 23: Pergamon Press: Oxford, UK, 1974.

  • Okubo H., Sako K., Toda H., Shin Y., and Yuki Y. Measuring of phthalate esters and phosphate esters in office rooms. Proceedings of the Annual Meeting on the Society of Indoor Environment, Japan, Vol. 3, pp. 2000, 126–129.

  • Otake T., Yoshinaga J., and Yanagisawa Y. Analysis of organic esters of plasticizer in indoor air by GC-MS and GC-FPD. Environ Sci Technol 2001: 35: 3099–3102.

    CAS  Article  Google Scholar 

  • Page B.D., and Lacroix G.M. The occurrence of phthalate ester and di-2-ethylhexyl adipate plasticizers in Canadian packaging and food sampled in 1985–1989: a survey. Food Additives Contamin 1995: 12: 129–151.

    CAS  Article  Google Scholar 

  • Paganetto G., Campi F., Varani K., Piffanelli A., Giovannini G., and Borea P.A. Endocrine-disrupting agents on healthy human tissues. Pharmacol Toxicol 2000: 86: 24–29.

    CAS  Article  Google Scholar 

  • Sharman M., Read W.A., Castle L., and Gilbert J. Levels of di-(2-ethylhexyl)phthalate and total phthalate esters in milk, cream, butter and cheese. Food Additives Contamin 1994: 11: 375–385.

    CAS  Article  Google Scholar 

  • Singh A.R., Lawrence W.H., and Autian J. Teratogenicity of phthalate esters in rats. J Pharm Sci 1972: 61: 51–55.

    CAS  Article  Google Scholar 

  • Sjodin A., Carlsson H., Thuresson K., Sjolin S., Bergman A., and Ostman C. Flame retardants in indoor air at an electronics recycling plant and at other work environments. Environ Sci Technol 2001: 35: 448–454.

    CAS  Article  Google Scholar 

  • Takeda K., Taira T., Yasuko S., Hiroshi F., Tatsuo N., Motohiko K., and Taketoshi F. Development of an evaluation method for phthalate esters in indoor air. Proceedings of the Annual Meeting on the Society of Indoor Environment, Japan, Vol. 3, pp. 2000, 118–121.

  • Thuren A., and Larsson P. Phthalate esters in the Swedish atmosphere. Environ Sci Technol 1990: 24: 554–559.

    CAS  Article  Google Scholar 

  • Tilson H.A., Veronesi B., Mclamb R.L., and Matthews H.B. Acute exposure to Tris(2-chloroethyl)phosphate produces hippocampal neuronal loss and impairs learning in rats. Toxicol Appl Pharmacol 1990: 106: 254–269.

    CAS  Article  Google Scholar 

  • Tsumura Y., Ishimitsu S., Saito I., Sakai H., Kobayashi Y., and Tonogai Y. Eleven phthalate esters and di(2-ethylhexyl) adipate in one-week duplicate diet samples obtained from hospitals and their estimated daily intake. Food Additives Contamin 2001: 18: 449–460.

    CAS  Article  Google Scholar 

  • World Health Organization. Environmental Health Criteria 189 di-n-butyl Phthalate. World Health Organization, Geneva, 1997.

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Acknowledgements

We thank Dr. H. Seto, Tokyo Metropolitan Research Laboratory of Public Health, and Dr. Y. Hanai, Yokohama National University, for valuable discussions. This study was supported by the Special Coordination Funds for Promoting Science and Technology of Science and Technology Agency, Japan.

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Correspondence to Takamitsu Otake.

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Otake, T., Yoshinaga, J. & Yanagisawa, Y. Exposure to phthalate esters from indoor environment. J Expo Sci Environ Epidemiol 14, 524–528 (2004). https://doi.org/10.1038/sj.jea.7500352

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  • DOI: https://doi.org/10.1038/sj.jea.7500352

Keywords

  • indoor air
  • phthalate esters
  • phosphate esters
  • inhalation exposure
  • GC/MS
  • GC/FPD.

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