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Time for an oil check: the role of essential omega-3 fatty acids in maternal and pediatric health

Journal of Perinatology volume 26, pages 359–365 (2006)Cite this article

Abstract

Deficiency of omega-3 fatty acids (ω3FAs) is an often unrecognized determinant of clinical disease; the adequate availability of these essential nutrients may prevent affliction or facilitate health restoration in some pregnant women and developing offspring. The human organism requires specific nutrients in order to carry out the molecular processes within cells and tissues and it is well established that ω3FAs are essential lipids necessary for various physiological functions. Accordingly, to achieve optimal health for patients, care givers should be familiar with clinical aspects of nutritional science, including the assessment of nutritional status and judicious use of nutrient supplementation. In view of the mounting evidence implicating ω3FA deficiency as a determinant of various maternal and pediatric afflictions, physicians should consider recommending purified fish oil supplementation during pregnancy and lactation. Furthermore, ω3FA supplementation may be indicated in selected pediatric situations to promote optimal health among children.

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References

  1. Simopoulos AP . Essential fatty acids in health and chronic diseases. Forum Nutr 2003; 56: 67–70.

    CAS  PubMed  Google Scholar 

  2. Siguel EN . Essential and trans fatty acid metabolism in health and disease. Compr Ther 1994; 20: 500–510.

    CAS  PubMed  Google Scholar 

  3. Singh M . Essential fatty acids, DHA and human brain. Indian J Pediatr 2005; 72: 239–242.

    Article  Google Scholar 

  4. Bralley JA, Lord RS . Laboratory Evaluations in Molecular Medicine: Nutrients, Toxicants, and Cell Regulators. The Institute for Advances in Molecular Medicine: Norcross, GA, 2005.

    Google Scholar 

  5. Simopoulos AP . The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother 2002; 56: 365–379.

    Article  CAS  Google Scholar 

  6. Simopoulos AP . Omega-3 fatty acids in inflammation and autoimmune diseases. J Am Coll Nutr 2002; 21: 495–505.

    Article  CAS  Google Scholar 

  7. Maillard V, Bougnoux P, Ferrari P, Jourdan ML, Pinault M, Lavillonniere F et al. N-3 and N-6 fatty acids in breast adipose tissue and relative risk of breast cancer in a case–control study in Tours, France. Int J Cancer 2002; 98: 78–83.

    Article  CAS  Google Scholar 

  8. Bucher HC, Hengstler P, Schindler C, Meier G . N-3 polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials. Am J Med 2002; 112: 298–304.

    Article  CAS  Google Scholar 

  9. Kremer JM, Lawrence DA, Jubiz W, DiGiacomo R, Rynes R, Bartholomew LE et al. Dietary fish oil and olive oil supplementation in patients with rheumatoid arthritis. Clinical and immunologic effects. Arthritis Rheum 1990; 33: 810–820.

    Article  CAS  Google Scholar 

  10. Helland IB, Smith L, Saarem K, Saugstad OD, Drevon CA . Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children's IQ at 4 years of age. Pediatrics 2003; 111: e39–e44.

    Article  Google Scholar 

  11. Linday L, Dolitsky J, Shindledecker R, Pippenger J . Lemon-flavored cod liver oil and a multivitamin–mineral supplement for the secondary prevention of otitis media in young children: pilot research. Ann Otol Rhinol Laryngol 2002; 111: 642–652.

    Article  Google Scholar 

  12. Iribarren C, Markovitz JH, Jacobs Jr DR, Schreiner PJ, Daviglus M, Hibbeln JR . Dietary intake of n-3, n-6 fatty acids and fish: relationship with hostility in young adults – the CARDIA study. Eur J Clin Nutr 2004; 58: 24–31.

    Article  CAS  Google Scholar 

  13. Haag M . Essential fatty acids and the brain. Can J Psychiatry 2003; 48: 195–203.

    Article  Google Scholar 

  14. Din JN, Newby DE, Flapan AD . Omega 3 fatty acids and cardiovascular disease – fishing for a natural treatment. BMJ 2004; 328: 30–35.

    Article  CAS  Google Scholar 

  15. Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Wilson RS et al. Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. Arch Neurol 2003; 60: 940–946.

    Article  Google Scholar 

  16. Luke B . Nutrition during pregnancy. Curr Opin Obstet Gynecol 1994; 6: 402–407.

    Article  CAS  Google Scholar 

  17. Nettleton JA . Are n-3 fatty acids essential nutrients for fetal and infant development? J Am Diet Assoc 1993; 93: 58–64.

    Article  CAS  Google Scholar 

  18. Uauy R, Hoffman DR, Peirano P, Birch DG, Birch EE . Essential fatty acids in visual and brain development. Lipids 2001; 36: 885–895.

    Article  CAS  Google Scholar 

  19. Wainwright PE . Dietary essential fatty acids and brain function: a developmental perspective on mechanisms. Proc Nutr Soc 2002; 61: 61–69.

    Article  CAS  Google Scholar 

  20. Uauy-Dagach R, Mena P . Nutritional role of omega-3 fatty acids during the perinatal period. Clin Perinatol 1995; 22: 157–175.

    Article  CAS  Google Scholar 

  21. Saldeen P, Saldeen T . Women and omega-3 fatty acids. Obstet Gynecol Surv 2004; 59: 722–730.

    Article  Google Scholar 

  22. Simopoulos AP . Omega-3 fatty acids in health and disease and in growth and development. Am J Clin Nutr 1991; 54: 438–463.

    Article  CAS  Google Scholar 

  23. Saldeen T . Fish Oil and Health. SwedeHealth Press: Uppsala, Sweden, 1997.

    Google Scholar 

  24. Innis SM, Elias SL . Intakes of essential n-6 and n-3 polyunsaturated fatty acids among pregnant Canadian women. Am J Clin Nutr 2003; 77: 473–478.

    Article  CAS  Google Scholar 

  25. Gerrard J, Popeski D, Ebbeling L, Brown P, Hornstra G . Dietary omega 3 fatty acids and gestational hypertension in the Inuit. Arctic Med Res 1991; (Suppl): 763–767.

  26. Williams MA, Zingheim RW, King IB, Zebelman AM . Omega-3 fatty acids in maternal erythrocytes and risk of pre-eclampsia. Epidemiology 1995; 6: 232–237.

    Article  CAS  Google Scholar 

  27. Appel LJ, Miller III ER, Seidler AJ, Whelton PK . Does supplementation of diet with ‘fish oil’ reduce blood pressure? A meta-analysis of controlled clinical trials. Arch Intern Med 1993; 153: 1429–1438.

    Article  CAS  Google Scholar 

  28. Geleijnse JM, Giltay EJ, Grobbee DE, Donders AR, Kok FJ . Blood pressure response to fish oil supplementation: metaregression analysis of randomized trials. J Hypertens 2002; 20: 1493–1499.

    Article  CAS  Google Scholar 

  29. Armitage JA, Pearce AD, Sinclair AJ, Vingrys AJ, Weisinger RS, Weisinger HS . Increased blood pressure later in life may be associated with perinatal n-3 fatty acid deficiency. Lipids 2003; 38: 459–464.

    Article  CAS  Google Scholar 

  30. McGregor JA, Allen KG, Harris MA, Reece M, Wheeler M, French JI et al. The omega-3 story: nutritional prevention of preterm birth and other adverse pregnancy outcomes. Obstet Gynecol Surv 2001; 56: S1–S13.

    Article  CAS  Google Scholar 

  31. Olsen SF, Secher NJ . Low consumption of seafood in early pregnancy as a risk factor for preterm delivery: prospective cohort study. BMJ 2002; 324: 447.

    Article  Google Scholar 

  32. Allen KG, Harris MA . The role of n-3 fatty acids in gestation and parturition. Exp Biol Med (Maywood) 2001; 226: 498–506.

    Article  CAS  Google Scholar 

  33. Hibbeln JR . Seafood consumption, the DHA content of mothers' milk and prevalence rates of postpartum depression: a cross-national, ecological analysis. J Affect Disord 2002; 69: 15–29.

    Article  CAS  Google Scholar 

  34. Makrides M, Crowther CA, Gibson RA, Gibson RS, Skeaff CM . Docosahexaenoic acid and post-partum depression – is there a link? Asia Pac J Clin Nutr 2003; 12(Suppl): S37.

    Google Scholar 

  35. Maes M, Christophe A, Delanghe J, Altamura C, Neels H, Meltzer HY . Lowered omega3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients. Psychiatry Res 1999; 85: 275–291.

    Article  CAS  Google Scholar 

  36. Mischoulon D, Fava M . Docosahexanoic acid and omega-3 fatty acids in depression. Psychiatr Clin North Am 2000; 23: 785–794.

    Article  CAS  Google Scholar 

  37. Otto SJ, de Groot RH, Hornstra G . Increased risk of postpartum depressive symptoms is associated with slower normalization after pregnancy of the functional docosahexaenoic acid status. Prostaglandins Leukot Essent Fatty Acids 2003; 69: 237–243.

    Article  CAS  Google Scholar 

  38. Nemets B, Stahl Z, Belmaker RH . Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder. Am J Psychiatry 2002; 159: 477–479.

    Article  Google Scholar 

  39. van Houwelingen AC, Sorensen JD, Hornstra G, Simonis MM, Boris J, Olsen SF et al. Essential fatty acid status in neonates after fish-oil supplementation during late pregnancy. Br J Nutr 1995; 74: 723–731.

    Article  CAS  Google Scholar 

  40. Willatts P . Long chain polyunsaturated fatty acids improve cognitive development. J Fam Health Care 2002; 12: 5.

    PubMed  Google Scholar 

  41. Petridou E, Koussouri M, Toupadaki N, Youroukos S, Papavassiliou A, Pantelakis S et al. Diet during pregnancy and the risk of cerebral palsy. Br J Nutr 1998; 79: 407–412.

    Article  CAS  Google Scholar 

  42. Bell JG, MacKinlay EE, Dick JR, MacDonald DJ, Boyle RM, Glen AC . Essential fatty acids and phospholipase A2 in autistic spectrum disorders. Prostaglandins Leukot Essent Fatty Acids 2004; 71: 201–204.

    Article  CAS  Google Scholar 

  43. Johnson SM, Hollander E . Evidence that eicosapentaenoic acid is effective in treating autism. J Clin Psychiatry 2003; 64: 848–849.

    Article  Google Scholar 

  44. Richardson AJ, Puri BK . The potential role of fatty acids in attention-deficit/hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids 2000; 63: 79–87.

    Article  CAS  Google Scholar 

  45. Stevens LJ, Zentall SS, Deck JL, Abate ML, Watkins BA, Lipp SR et al. Essential fatty acid metabolism in boys with attention-deficit hyperactivity disorder. Am J Clin Nutr 1995; 62: 761–768.

    Article  CAS  Google Scholar 

  46. Richardson AJ . Clinical trials of fatty acid treatment in ADHD, dyslexia, dyspraxia and the autistic spectrum. Prostaglandins Leukot Essent Fatty Acids 2004; 70: 383–390.

    Article  CAS  Google Scholar 

  47. Vancassel S, Durand G, Barthelemy C, Lejeune B, Martineau J, Guilloteau D et al. Plasma fatty acid levels in autistic children. Prostaglandins Leukot Essent Fatty Acids 2001; 65: 1–7.

    Article  CAS  Google Scholar 

  48. Stordy BJ . Dark adaptation, motor skills, docosahexaenoic acid, and dyslexia. Am J Clin Nutr 2000; 71: 323S–326S.

    Article  CAS  Google Scholar 

  49. Taylor KE, Higgins CJ, Calvin CM, Hall JA, Easton T, McDaid AM et al. Dyslexia in adults is associated with clinical signs of fatty acid deficiency. Prostaglandins Leukot Essent Fatty Acids 2000; 63: 75–78.

    Article  CAS  Google Scholar 

  50. Richardson AJ, Montgomery P . The Oxford–Durham study: a randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder. Pediatrics 2005; 115: 1360–1366.

    Article  Google Scholar 

  51. Birch EE, Garfield S, Hoffman DR, Uauy R, Birch DG . A randomized controlled trial of early dietary supply of long-chain polyunsaturated fatty acids and mental development in term infants. Dev Med Child Neurol 2000; 42: 174–181.

    Article  CAS  Google Scholar 

  52. Richardson AJ, Calvin CM, Clisby C, Schoenheimer DR, Montgomery P, Hall JA et al. Fatty acid deficiency signs predict the severity of reading and related difficulties in dyslexic children. Prostaglandins Leukot Essent Fatty Acids 2000; 63: 69–74.

    Article  CAS  Google Scholar 

  53. McCann JC, Ames BN . Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals. Am J Clin Nutr 2005; 82: 281–295.

    Article  CAS  Google Scholar 

  54. Stene LC, Ulriksen J, Magnus P, Joner G . Use of cod liver oil during pregnancy associated with lower risk of type I diabetes in the offspring. Diabetologia 2000; 43: 1093–1098.

    Article  CAS  Google Scholar 

  55. Merzouk H, Khan NA . Implication of lipids in macrosomia of diabetic pregnancy: can n-3 polyunsaturated fatty acids exert beneficial effects? Clin Sci (London) 2003; 105: 519–529.

    Article  CAS  Google Scholar 

  56. Stene LC, Joner G . Use of cod liver oil during the first year of life is associated with lower risk of childhood-onset type 1 diabetes: a large, population-based, case–control study. Am J Clin Nutr 2003; 78: 1128–1134.

    Article  CAS  Google Scholar 

  57. Ailhaud G, Guesnet P . Fatty acid composition of fats is an early determinant of childhood obesity: a short review and an opinion. Obes Rev 2004; 5: 21–26.

    Article  CAS  Google Scholar 

  58. Massiera F, Saint-Marc P, Seydoux J, Murata T, Kobayashi T, Narumiya S et al. Arachidonic acid and prostacyclin signaling promote adipose tissue development: a human health concern? J Lipid Res 2003; 44: 271–279.

    Article  CAS  Google Scholar 

  59. SanGiovanni JP, Parra-Cabrera S, Colditz GA, Berkey CS, Dwyer JT . Meta-analysis of dietary essential fatty acids and long-chain polyunsaturated fatty acids as they relate to visual resolution acuity in healthy preterm infants. Pediatrics 2000; 105: 1292–1298.

    Article  CAS  Google Scholar 

  60. Hoffman DR, Birch EE, Birch DG, Uauy R, Castaneda YS, Lapus MG et al. Impact of early dietary intake and blood lipid composition of long-chain polyunsaturated fatty acids on later visual development. J Pediatr Gastroenterol Nutr 2000; 31: 540–553.

    Article  CAS  Google Scholar 

  61. SanGiovanni JP, Berkey CS, Dwyer JT, Colditz GA . Dietary essential fatty acids, long-chain polyunsaturated fatty acids, and visual resolution acuity in healthy fullterm infants: a systematic review. Early Hum Dev 2000; 57: 165–188.

    Article  CAS  Google Scholar 

  62. Uauy R, Hoffman DR, Mena P, Llanos A, Birch EE . Term infant studies of DHA and ARA supplementation on neurodevelopment: results of randomized controlled trials. J Pediatr 2003; 143: S17–S25.

    Article  CAS  Google Scholar 

  63. Clandinin MT, Van Aerde JE, Merkel KL, Harris CL, Springer MA, Hansen JW et al. Growth and development of preterm infants fed infant formulas containing docosahexaenoic acid and arachidonic acid. J Pediatr 2005; 146: 461–468.

    Article  CAS  Google Scholar 

  64. Birch EE, Castaneda YS, Wheaton DH, Birch DG, Uauy RD, Hoffman DR . Visual maturation of term infants fed long-chain polyunsaturated fatty acid-supplemented or control formula for 12 mo. Am J Clin Nutr 2005; 81: 871–879.

    Article  CAS  Google Scholar 

  65. Birch EE, Hoffman DR, Uauy R, Birch DG, Prestidge C . Visual acuity and the essentiality of docosahexaenoic acid and arachidonic acid in the diet of term infants. Pediatr Res 1998; 44: 201–209.

    Article  CAS  Google Scholar 

  66. Lo C . Integrating nutrition as a theme throughout the medical school curriculum. Am J Clin Nutr 2000; 72: 882S–889S.

    Article  CAS  Google Scholar 

  67. Mihalynuk TV, Scott CS, Coombs JB . Self-reported nutrition proficiency is positively correlated with the perceived quality of nutrition training of family physicians in Washington State. Am J Clin Nutr 2003; 77: 1330–1336.

    Article  CAS  Google Scholar 

  68. Global strategy on diet, physical activity and health. WHA57.17. World Health Organization: Geneva, 2004.

  69. Department of Health and Human Services (HHS) and the Department of Agriculture (USDA). Dietary Guidelines for Americans 2005, http://www.healthierus.gov/dietaryguidelines/(Accessed May 2, 2005).

  70. Centers for Disease Control, National Center for Chronic Disease Prevention and Health Promotion. Physical activity and good nutrition: essential elements to prevent chronic diseases and obesity 2003. Nutr Clin Care 2003; 6: 135–138.

  71. Genuis SJ . Nutritional transition: a determinant of global health. J Epidemiol Commun Health 2005; 59: 615–617.

    Article  Google Scholar 

  72. Simopoulos AP . n-3 fatty acids and human health: defining strategies for public policy. Lipids 2001; 36(Suppl): S83–S89.

    Article  CAS  Google Scholar 

  73. Bjerregaard P, Hansen JC . Organochlorines and heavy metals in pregnant women from the Disko Bay area in Greenland. Sci Total Environ 2000; 245: 195–202.

    Article  CAS  Google Scholar 

  74. Matthiessen P, Sumpter JP . Effects of estrogenic substances in the aquatic environment. EXS 1998; 86: 319–335.

    CAS  PubMed  Google Scholar 

  75. Olsen SF . Mercury, PCB, and now eicosapentaenoic acid: still another reason why pregnant women should be concerned about eating seafood? Int J Epidemiol 2001; 30: 1279–1280.

    Article  CAS  Google Scholar 

  76. Sehmer J . Mercury in seafood. Can Med Assoc J 2002; 167: 122, 124.

    Google Scholar 

  77. Heberer T . Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Toxicol Lett 2002; 131: 5–17.

    Article  CAS  Google Scholar 

  78. Sakamoto M, Kubota M, Liu XJ, Murata K, Nakai K, Satoh H . Maternal and fetal mercury and n-3 polyunsaturated fatty acids as a risk and benefit of fish consumption to fetus. Environ Sci Technol 2004; 38: 3860–3863.

    Article  CAS  Google Scholar 

  79. Dooks P . Diffusion of pain management research into nursing practice. Cancer Nursing 2001; 2: 99–103.

    Article  Google Scholar 

  80. Smithells RW, Sheppard S, Schorah CJ . Vitamin deficiencies and neural tube defects. Arch Dis Child 1976; 51: 944–950.

    Article  CAS  Google Scholar 

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  1. Faculty of Medicine-OB/GYN, University of Alberta, Edmonton, AB, Canada

    S J Genuis

  2. Department of Family Medicine, Misericordia Health Facility, Edmonton, AB, Canada

    G K Schwalfenberg

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Correspondence to S J Genuis.

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Genuis, S., Schwalfenberg, G. Time for an oil check: the role of essential omega-3 fatty acids in maternal and pediatric health. J Perinatol 26, 359–365 (2006). https://doi.org/10.1038/sj.jp.7211519

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