Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

The Association between Early Tracheal Colonization and Bronchopulmonary Dysplasia

Journal of Perinatology volume 25, pages 403–407 (2005)Cite this article

Abstract

OBJECTIVE:

To evaluate the relationship between early tracheal colonization and bronchopulmonary dysplasia (BPD).

STUDY DESIGN:

This is a retrospective cohort study which included 308 inborn neonates admitted to the newborn intensive care unit at the University of Miami Jackson Memorial Medical Center between January 1997 and December 2000 with birthweight 500 to 1000 g, who required mechanical ventilation on the first day of life. Chorioamnionitis was diagnosed by maternal symptoms and histopathopathology. Tracheal cultures were obtained immediately after tracheal intubation. BPD was diagnosed in neonates who had supplemental oxygen requirement for more than 28 days. Pearson's χ2 and Logistic Regression Analysis were used to evaluate the relationship between chorioamnionitis, positive initial tracheal cultures and BPD, after adjusting for confounding variables.

RESULTS:

In patients with chorioamnionitis, the incidence of early positive tracheal cultures was 41% compared to 16% in those without chorioamnionitis, (p<0.00001). In patients with birthweight 700 to 1000 g, a positive early tracheal culture increased the risk of BPD (OR=2.42, CI 1.05 to 5.62, p<0.05).

CONCLUSION:

Preterm infants exposed to chorioamnionitis have an increased incidence of early tracheal colonization. This early tracheal colonization may predispose them to develop BPD.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Jobe AH . Antenatal factors and the development of bronchopulmonary dysplasia. Semin Neonatol 2003;8(1):9–17.

    Article  Google Scholar 

  2. Schmidt B, Cao L, Mackensen-Haen S, Kendziorra H, Klingel K, Speer CP . Chorioamnionitis and inflammation of the fetal lung. Am J Obstet Gynecol 2001;185(1):173–177.

    Article  CAS  Google Scholar 

  3. Speer CP . Inflammation and bronchopulmonary dysplasia. Semin Neonatol 2003;8(1):29–38.

    Article  Google Scholar 

  4. Sherman MP, Goetzman BW, Ahlfors CE, Wennberg RP . Tracheal aspiration and its clinical correlates in the diagnosis of congenital pneumonia. Pediatrics 1980;65(2):258–263.

    CAS  PubMed  Google Scholar 

  5. Bancalari E, Abdenour GE, Feller R, Gannon J . Bronchopulmonary dysplasia: clinical presentation. J Pediatr 1979;95(5 Part 2):819–823.

    Article  CAS  Google Scholar 

  6. Jobe AH, Bancalari E . Bronchopulmonary dysplasia. Am J Respir Crit Care Med 2001;163(7):1723–1729.

    Article  CAS  Google Scholar 

  7. Bhandari V, Hussain N, Rosenkrantz T, Kresch M . Respiratory tract colonization with mycoplasma species increases the severity of bronchopulmonary dysplasia. J Perinat Med 1998;26(1):37–42.

    Article  CAS  Google Scholar 

  8. Couroucli XI, Welty SE, Ramsay PL, et al. Detection of microorganisms in the tracheal aspirates of preterm infants by polymerase chain reaction: association of adenovirus infection with bronchopulmonary dysplasia. Pediatr Res 2000;47(2):225–232.

    Article  CAS  Google Scholar 

  9. Hannaford K, Todd DA, Jeffery H, John E, Blyth K, Gilbert GL . Role of ureaplasma urealyticum in lung disease of prematurity. Arch Dis Child Fetal Neonatal Ed 1999;81(3):F162–F167.

    Article  CAS  Google Scholar 

  10. Goldenberg RL, Hauth JC, Andrews WW . Intrauterine infection and preterm delivery. N Engl J Med 2000;342(20):1500–1507.

    Article  CAS  Google Scholar 

  11. Taeusch Jr HW, Frigoletto F, Kitzmiller J, et al. Risk of respiratory distress syndrome after prenatal dexamethasone treatment. Pediatrics 1979;63(1):64–72.

    PubMed  Google Scholar 

  12. Vermillion ST, Soper DE, Chasedunn-Roark J . Neonatal sepsis after betamethasone administration to patients with preterm premature rupture of membranes. Am J Obstet Gynecol 1999;181(2):320–327.

    Article  CAS  Google Scholar 

  13. Watterberg KL, Scott SM, Naeye RL . Chorioamnionitis, cortisol, and acute lung disease in very low birth weight infants. Pediatrics 1997;99(2):E6.

    Article  CAS  Google Scholar 

  14. Shimoya K, Taniguchi T, Matsuzaki N, et al. Chorioamnionitis decreased incidence of respiratory distress syndrome by elevating fetal interleukin-6 serum concentration. Hum Reprod 2000;15(10):2234–2240.

    Article  CAS  Google Scholar 

  15. Kramer BW, Moss TJ, Willet KE, et al. Dose and time response after intraamniotic endotoxin in preterm lambs. Am J Respir Crit Care Med 2001;164(6):982–988.

    Article  CAS  Google Scholar 

  16. Watterberg KL, Demers LM, Scott SM, Murphy S . Chorioamnionitis and early lung inflammation in infants in whom bronchopulmonary dysplasia develops. Pediatrics 1996;97(2):210–215.

    CAS  Google Scholar 

  17. Kramer BW, Kramer S, Ikegami M, Jobe AH . Injury, inflammation, and remodeling in fetal sheep lung after intra-amniotic endotoxin. Am J Physiol Lung Cell Mol Physiol 2002;283(2):L452–L459.

    Article  CAS  Google Scholar 

  18. Yoon BH, Romero R, Jun JK, et al. Amniotic fluid cytokines (interleukin-6, tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-8) and the risk for the development of bronchopulmonary dysplasia. Am J Obstet Gynecol 1997;177(4):825–830.

    Article  CAS  Google Scholar 

  19. Tremblay L, Valenza F, Ribeiro SP, Li J, Slutsky AS . Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model. J Clin Invest 1997;99(5):944–952.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by the University of Miami Project New Born, and presented in part at the Society for Pediatric Research, May 2001, Baltimore, MD, USA.

Author information

Authors and Affiliations

  1. Division of Newborn Medicine, Department of Pediatrics, University of Miami School of Medicine, Miami, FL, USA

    Karen C Young MD, Teresa del Moral MD, MPH, Nelson Claure PhD, Silvia Vanbuskirk RN, BSN & Eduardo Bancalari MD

Authors
  1. Karen C Young MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Teresa del Moral MD, MPH
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nelson Claure PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Silvia Vanbuskirk RN, BSN
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Eduardo Bancalari MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Young, K., del Moral, T., Claure, N. et al. The Association between Early Tracheal Colonization and Bronchopulmonary Dysplasia. J Perinatol 25, 403–407 (2005). https://doi.org/10.1038/sj.jp.7211297

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.jp.7211297

This article is cited by

Search

Advanced search

Quick links