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Association between Lenticulostriate Vasculopathy (LSV) and Neonatal Intraventricular Hemorrhage (IVH)

Journal of Perinatology volume 24, pages 700–705 (2004)Cite this article

Abstract

OBJECTIVES: To determine whether there is an unconfounded association between neonatal intraventricular hemorrhage (IVH) and lenticulostriate vasculopathy (LSV (also known as thalamostriate or mineralizing vasculopathy)).

STUDY DESIGN: During the conduct of the Magnesium and Neurologic Endpoints Trial (MagNET), a randomized controlled trial involving maternal, hence fetal, exposure to antenatal magnesium sulfate in the context of preterm labor, head ultrasounds were obtained for each of the surviving neonates. Because of our previous experience in the diagnosis of LSV, when ascertaining the presence of IVH, as called for by the research protocol of our study, the presence or absence of LSV was also determined.

RESULTS: We found LSV to be relatively prevalent (10% (14 of 140) among surviving babies). More importantly, it was significantly associated with the occurrence of neonatal IVH, even when controlled for possible confounding (adjusted OR 9.8, 95% confidence interval 1.3 to 73.1; p=0.03).

CONCLUSION: Given the known relationships between IVH and neonatal morbidity and mortality, the finding of a statistically significant association between neonatal IVH and LSV may suggest more substantial implications for the latter than previously believed.

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Acknowledgements

Funding for the Magnesium and Neurologic Endpoints Trial was provided by the United Cerebral Palsy Research and Educational Foundation, Washington, DC.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Loyola University Medical Center, Maywood, IL, USA

    Robert Mittendorf MD, DrPH

  2. Department of Pediatrics, Section of Neonatology, University of Chicago Children's Hospital, Chicago, IL, USA

    Robert Covert MD & Kwang-Sun Lee MD

  3. University of Wisconsin Medical School, Madison, WI, USA

    Peter G Pryde MD

  4. Department of Medical Imaging, Children's Memorial Hospital, Chicago, IL, USA

    Tamar Ben-Ami MD

  5. Department of Radiology, Section of Pediatric Radiology, University of Chicago, Chicago, IL, USA

    David Yousefzadeh MD

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  1. Robert Mittendorf MD, DrPH
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Mittendorf, R., Covert, R., Pryde, P. et al. Association between Lenticulostriate Vasculopathy (LSV) and Neonatal Intraventricular Hemorrhage (IVH). J Perinatol 24, 700–705 (2004). https://doi.org/10.1038/sj.jp.7211173

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