Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Perinatal/Neonatal Case Presentation
  • Published:

Perinatal/Neonatal Case Presentation

A Case of Wilson-Mikity Syndrome With High Serum KL-6 Levels

Journal of Perinatology volume 23, pages 56–58 (2003)Cite this article

Abstract

KL-6 and surfactant protein D (SP-D) serum concentrations are known to rise in adult patients with various types of interstitial pneumonia. We evaluated the time course of serum KL-6, SP-D, and lactate dehydrogenase (LDH) levels in an infant with Wilson-Mikity syndrome. In this case, serum KL-6 levels correlated with clinical symptoms better than serum SP-D and LDH levels. The findings of this case suggest that high serum levels of KL-6 show activity of interstitial lung disease of Wilson-Mikity syndrome.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

Similar content being viewed by others

References

  1. Hodgman JE, Mikity VG, Tatter D, Cleland RS . Chronic respiratory distress in the premature infants: Wilson-Mikity syndrome. Pediatrics 1969; 44: 179–95.

    CAS  PubMed  Google Scholar 

  2. Fujimura M, Takeuchi T, Kitajima H, Nakayama M . Chorioamnionitis and serum IgM in Wilson-Mikity syndrome. Arch Dis Child 1989; 64: 1379–83.

    Article  CAS  Google Scholar 

  3. Watterberg KL, Demers LM, Scott SM, Murphy S . Chorioamnionitis and early lung inflammation in infants in whom bronchopulmonary dysplasia develops. Pediatrics 1996; 97: 210–5.

    CAS  PubMed  Google Scholar 

  4. Ogawa Y, Fujimura M, Goto A, et al. Epidemiology of neonatal chronic lung disease in Japan. Acta Paediatr Jpn 1992; 34: 663–7.

    Article  CAS  Google Scholar 

  5. Khono N, Kyoizumi S, Awaya Y, Fukuhara H, Yamakido M, Akiyama M . New serum indicator of interstitial pneumonitis activity: sialylated carbohydrate antigen KL-6. Chest 1989; 96: 68–73.

    Article  Google Scholar 

  6. Honda Y, Kuroki Y, Matsuura E, et al. Pulmonary surfactant protein D in sera and bronchoalveolar lavage fluids. Am J Respir Crit Care Med 1995; 152: 1860–6.

    Article  CAS  Google Scholar 

  7. Khono N, Akiyama M, Kyoizumi S, Hakoda M, Kobuke K, Yamakido M . Detection of soluble tumor-associated antigens in sera and effusions using novel monoclonal antibodies, KL-3 and KL-6, against lung adenocarcinoma. Jpn J Clin Oncol 1998; 18: 203–16.

    Google Scholar 

  8. Inoue T, Matsuura E, Nagata A, et al. Enzyme-linked, immunosorbent assay for human pulmonary surfactant protein D. J Immunol Methods 1994; 173: 157–64.

    Article  CAS  Google Scholar 

  9. Kobayashi J, Itoh Y, Kitamura S, Kawai T . Establishment of reference intervals and cut-off value by an enzyme immunoassay for KL-6 antigen, a new marker for interstitial pneumonia. Jpn J Clin Pathol 1996; 44: 653–8.

    CAS  Google Scholar 

  10. Honda Y . Clinical evaluation of surfactant protein D kit “Yamasa” in various lung diseases. Igaku To Yakugaku 1996; 36: 809–15(in Japanese)

    Google Scholar 

  11. Ogihara T, Kazuya H, Morinobu T, et al. KL-6, a mucinous glycoprotein, as an indicator of chronic lung disease of newborn. J Pediatr 2000; 137: 280–2.

    Article  CAS  Google Scholar 

  12. Takami T, Takei Y, Tachibana M, Kumada A, Miyajima T, Hoshika A . Serum KL-6 and SP-D in acute-phase of neonates with meconium aspiration syndrome. J Jpn Pediatr Soc 2002; 106: 383–8(in Japanese).

    Google Scholar 

  13. Takami T, Takei Y, Kumada A, et al. Serum KL-6 and SP-D levels in acute-phase of neonates with respiratory diseases. J Jpn Soc Prematur Newborn Med 2000; 12: 353(in Japanese).

    Google Scholar 

  14. DeRemee RA . Serum lactic dehydrogenase activity and diffuse interstitial pneumonitis. JAMA 1968; 204: 1193–5.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, Japan

    Takeshi Takami MD, Atsushi Kumada MD, Yukito Takei MD, Tasuku Miyajima MD & Akinori Hoshika MD

Authors
  1. Takeshi Takami MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Atsushi Kumada MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yukito Takei MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tasuku Miyajima MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Akinori Hoshika MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Takami, T., Kumada, A., Takei, Y. et al. A Case of Wilson-Mikity Syndrome With High Serum KL-6 Levels. J Perinatol 23, 56–58 (2003). https://doi.org/10.1038/sj.jp.7210830

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.jp.7210830

Search

Advanced search

Quick links