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P-Glycoprotein and Bilirubin Disposition

Journal of Perinatology volume 21, pages S43–S47 (2001)Cite this article

Abstract

P-glycoprotein (Pgp), an ATP-dependent plasma membrane efflux pump, is expressed in abundance on the luminal aspect of brain capillary endothelial cells and astrocytes of the blood–brain barrier where it limits the passage of a variety of lipophilic substrates into the central nervous system. This review summarizes current evidence characterizing (1) unconjugated bilirubin as a potential substrate for Pgp and (2) the ontogeny of Pgp expression at the blood–brain barrier and apical brush border epithelium of the gastrointestinal tract, findings that may provide insights regarding the disposition of bilirubin in immature subjects.

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Authors and Affiliations

  1. Division of Neonatology and Developmental Biology, Department of Pediatrics, University of Pittsburgh School of Medicine, Magee-Womens Research Institute, Pittsburgh, PA

    Jon F Watchko MD, Monica J Daood BS, Burhan Mahmood MD, Kalyani Vats MD & Claudia Hart MD

  2. WHY-NMD Institute, Pittsburgh, PA

    M Ahdab-Barmada MD

Authors
  1. Jon F Watchko MD
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  2. Monica J Daood BS
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  3. Burhan Mahmood MD
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  4. Kalyani Vats MD
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  5. Claudia Hart MD
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  6. M Ahdab-Barmada MD
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Additional information

This work was supported by grants HD-35847 and NS-38993 from the National Institutes of Health, the Irene McClenahan Young Investigator Research Fund of the Magee-Womens Health Research Foundation, the Mario Lemieux Centers for Patient Care and Research, and the 25 Club of Magee-Womens Hospital.

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Watchko, J., Daood, M., Mahmood, B. et al. P-Glycoprotein and Bilirubin Disposition. J Perinatol 21 (Suppl 1), S43–S47 (2001). https://doi.org/10.1038/sj.jp.7210633

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