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QTc Interval in Infants Receiving Cisapride

Journal of Perinatology volume 22, pages 144–148 (2002)Cite this article

Abstract

OBJECTIVE: To examine the effect of cisapride on the corrected QT (QTc) interval in infants over a 14-day period.

STUDY DESIGN: A prospective cohort study of infants receiving cisapride (0.8 mg/kg per day). Twelve-lead electrocardiograms were obtained before and 3, 5, 7, and 14 days after cisapride initiation.

RESULTS: Fifty infants completed the study; none had arrhythmias. Fifteen of 50 infants (30%) developed QTc interval ≥450 msec; QTc interval normalized in 13 of 15 infants. Infants with QTc interval on day 3 ≥2 standard deviations above the mean baseline QTc interval (401+40 msec) were more likely to develop prolonged QTc interval (p<0.0001).

CONCLUSION: QTc interval prolongation was noted in 30% of infants. Subsequently, the majority of those infants had QTc interval normalization by day 14 of cisapride therapy. QTc interval 3 days following cisapride initiation may identify infants at risk for transient QTc interval prolongation. With appropriate monitoring, hospitalized infants receiving cisapride may have improved gastrointestinal motility without cardiac morbidity.

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Authors and Affiliations

  1. Doctor's Hospital, Laredo, TX, USA

    Satbir Chhina MD

  2. Division of Neonatology, Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, CA, USA

    Ricardo L Peverini MD, Douglas D Deming MD, Andrew O Hopper MD & Nidia R Vyhmeister MD

  3. Division of Pediatric Cardiology, Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, CA, USA

    Aijaz Hashmi MD

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  1. Satbir Chhina MD
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  3. Douglas D Deming MD
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  6. Nidia R Vyhmeister MD
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Chhina, S., Peverini, R., Deming, D. et al. QTc Interval in Infants Receiving Cisapride. J Perinatol 22, 144–148 (2002). https://doi.org/10.1038/sj.jp.7210613

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