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  • Perinatal/Neonatal Casebook
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Perinatal/Neonatal Case Book

Transposition of the Great Arteries and Hypocalcemia in a Patient With Fetal Hydantoin Syndrome

Journal of Perinatology volume 22, pages 89–90 (2002)Cite this article

Abstract

We report a patient with fetal hydantoin syndrome (FHS) with associated d-transposition of the great arteries (d-TGA) and persistent hypocalcemia. d-TGA and hypocalcemia have each been individually reported once in association with FHS, but these patients were also prenatally exposed to phenobarbital. To our knowledge, this is the first report of these problems occurring after prenatal exposure to hydantoin alone. The combination of congenital heart disease and hypocalcemia in our patient raises the possibility of a hydantoin effect on neural crest migration.

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Authors and Affiliations

  1. Department of Human Genetics and Pediatrics, Division of Neonatology, Tulane University School of Medicine, New Orleans, LA, USA

    Mrugeshkumar K Shah MD, MPH, MS, Eva Morava MD, William Gill MD & Michael R Marble MD

Authors
  1. Mrugeshkumar K Shah MD, MPH, MS
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  2. Eva Morava MD
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  3. William Gill MD
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  4. Michael R Marble MD
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Shah, M., Morava, E., Gill, W. et al. Transposition of the Great Arteries and Hypocalcemia in a Patient With Fetal Hydantoin Syndrome. J Perinatol 22, 89–90 (2002). https://doi.org/10.1038/sj.jp.7210596

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