Sir,

I thank Dr Stewart for his interest in this case. We only performed scleral indentation at the end of the case to check the ora serrata near the entry sites, and during this procedure the cannula was plugged. The procedure was completely routine in every aspect, so we do not believe there were any case-specific risk factors for endophthalmitis. We remain concerned as to whether there is an increased risk of infection associated with the use of sutureless vitrectomy systems, and await further data from case reports and future trials.