Abstract
One of the most severe side effects of anti-tumour chemotherapy is mucositis due to drug toxicity for rapidly dividing cells. We show here that anti-DXR monoclonal antibodies can prevent DXR-induced damage. Indeed, apoptosis, confined to the proliferative compartment of the basal mucosa, observed in the tongue of DXR-treated mice was completely inhibited by topical application of the anti-DXR antibodies. © 2001 Cancer Research Campaign http://www.bjcancer.com
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Balsari, A., Rumio, C., Morelli, D. et al. Topical administration of a doxorubicin-specific monoclonal antibody prevents drug-induced mouth apoptosis in mice. Br J Cancer 85, 1964–1967 (2001). https://doi.org/10.1054/bjoc.2001.2188
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DOI: https://doi.org/10.1054/bjoc.2001.2188