Abstract
2–18% of ductal carcinoma-No Special Type (NST) are reported to express basal cell keratin 14 and such tumours may have a different metastatic pattern and prognosis. We performed immunohistochemistry for cytokeratins 19 (luminal) and 14 (basal) on 92 ductal carcinoma-NST. Those tumours showing CK14 expression were further characterized by immunohistochemistry for myoepithelial cell phenotype and analysed by comparative genomic hybridization. The 7 cases of ductal carcinoma-NST exhibiting a basal cell phenotype were all grade III tumours and showed a molecular cytogenetic profile similar to more conventional myoepithelial cell carcinomas. Therefore it appears that grade III invasive ductal carcinomas contain a subset of tumours with specific morphological and cytogenetic characteristics, and probably prognosis for the patient. © 2001 Cancer Research Campaign
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References
Accurso A, Donofrio V, Insabato L and Mosella G (1990) Adenomyoepithelioma of the breast. A case report. Tumori 76: 606–610
Barnes DM, Harris WH, Smith P, Millis RR and Rubens RD (1996) Immunohistochemical determination of oestrogen receptors: comparison of different methods of assessment of staining and correlation with clinical outcome of breast cancer patients. Br J Cancer 74: 1445–1451
Buerger H, Otterbach F, Simon R, Schäfer K-L, Poremba C, Diallo R, Brinkschmidt C, Dockhorn-Dworniczak B and Boecker W (1999) Different genetic pathways in the evolution of invasive breast cancer are associated with distinct morphological subtypes. J Pathol 189: 521–526
Dairkee SH, Puett L and Kackett AJ (1988) Expression of basal and luminal epithelium-specific keratins in normal, benign and malignant breast tissue. J Natl Cancer Inst 80: 691–695
Damiani S, Riccioni L, Pasquinelli G and Eusebi V (1997) Poorly differentiated myoepithelial cell rich carcinoma of the breast. Histopathology 30: 542–548
Desautels JE (1990) Malignant myoepithelioma of the breast: a case report. Can Assoc Radiol J 41: 387–388
Ellis IO, Dowsett M, Bartlett J, Walker R, Cooke T, Gullick W, Gusterson B, Mallon E and Barrett Lee P (2000) Recommendations for HER2 testing in the UK. J Clin Pathol 53: 890–892
Erlandson RA and Rosen PP (1982) Infiltrating myoepithelioma of the breast. Am J Surg Pathol 6: 785–793
Eusebi V, Casadei GP, Bussolati G and Azzopardi JG (1987) Adenomyoepithelioma of the breast with a distinctive type of apocrine adenosis. Histopathology 11: 305–315
Foschini MP and Eusebi V (1998) Carcinomas of the breast showing myoepithelial cell differentiation. Virchows Arch 432: 303–310
Foschini MP, Scarpellini F, Gown AM and Eusebi V Differential expression of myoepithelial markers in salivary, sweat and mammary glands. Int J Surg Pathol 2000, 8: 29–37
Gould VE, Koukoulis GK, Jansson DS, Nagle RB, Franke WW and Moll R (1990) Coexpression patterns of vimentin and glial filament protein with cytokeratins in the normal, hyperplastic and neoplastic breast. Am J Pathol 137: 1143–1155
Guelstein VI, Tchypysheva TA, Ermilova VD, Litvinova LV, Troyanovsky SM and Bannikov GA (1988) Monoclonal antibody mapping of keratins 8 and 17 and of vimentin in normal human mammary gland, benign tumors, dysplasias and breast cancer. Int J Cancer 42: 147–153
Gusterson BA, Warburton MJ, Mitchell D, Ellison M, Neville AM and Rudland PS (1982) Distribution of myoepithelial cells and basement membrane proteins in the normal breast and in benign and malignant breast diseases. Cancer Res 42: 4763–4770
Johannsson OT, Idvall I, Anderson C, Borg A, Barkardottir RB, Egilsson V and Olsson H (1997) Tumour biological features of BRCA1-induced breast and ovarian cancer. Eur J Cancer 33: 362–371
Jones C, Foschini MP, Chaggar R, Lu Y-J, Wells D, Shipley JM, Eusebi V and Lakhani SR (2000) Comparative genomic hybridization analysis of myoepithelial carcinoma of the breast. Laboratory Investigation 80: 831–836
Lakhani SR, O'Hare MJ, Monaghan P, Winehouse J, Gazet JC and Sloane JP (1995) Malignant myoepithelioma (myoepithelial carcinoma) of the breast: a detailed cytokeratin study. J Clin Pathol 48: 164–167
Lakhani SR, Chaggar R, Davies S, Jones C, Collins N, Odel C, Stratton MR and O'Hare MJ (1999) Genetic alterations in ‘normal’ luminal and myoepithelial cells of the breast. J. Pathology 189: 496–503
Malzahn K, Mitze M, Thoenes M and Moll R (1998) Biological and prognostic significance of stratified epithelial cytokeratins in infiltrating ductal breast carcinomas. Virchows Arch 433: 119–129
Nagle RB, Bocker W, Davis JR, Heid HW, Kaufmann M, Lucas DO and Jarasch ED (1986) Characterization of breast carcinomas by two monoclonal antibodies distinguishing myoepithelial from luminal epithelial cells. J Histochem Cytochem 34: 869–881
National Coordinating Group for Breast Screening Pathology (1995) Pathology reporting in breast cancer screening. NHS Breast Screening Programme Publication No.3, NHSBSP Publications: Sheffield
Nishizaki T, DeVries S, Chew K, Goodson, III WH, Ljung B-M, Thor A and Waldman FM (1997) Genetic alterations in primary breast cancers and their metastases: direct comparison using modified comparative genomic hybridization. Genes Chromosomes Cancer 19: 267–272
Perou CM, Sørlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, Fluge Ø, Pergamenschikov A, Williams C, Zhu SX, Lønning PE, Børresen-Dale A-L, Brown PO and Botstein D (2000) Molecular portraits of human breast tumours. Nature 406: 747–752
Roylance R, Gorman P, Harris W, Liebmann R, Barnes D, Hanby A and Sheer D (1999) Comparative genomic hybridization of breast tumors stratified by histological grade reveals new insights into the biological progression of breast cancer. Cancer Res 59: 1433–1436
Schwendel A, Richard F, Langreck H, Kaufmann O, Lage H, Winzer KJ, Petersen I and Dietel M (1998) Chromosome alterations in breast carcinomas: frequent involvement of DNA losses including chromosomes 4q and 21q. Br. J. Cancer 78: 806–811
Shiraishi T, Nakayama T, Fukutome K, Watanabe M and Murata T (1999) Malignant myoepithelioma of the breast metastasising to the jaw. Virchows Arch 435: 520–523
Tavassoli FA (1991) “Myoepithelial lesions of the breast. Myoepitheliosis, adenomyoepithclioma, and myoepithelial carcinoma. Am J Surg Pathol 15: 554–568
Thorner PS, Kahn HJ, Baumal R, Lee K and Moffatt W (1986) Malignant myoepithelioma of the breast. An immunohistochemical study by light and electron microscopy. Cancer 57, (4): 745–750
Tirkkonen M, Tanner M, Karhu R, Kallioniemi A, Isola J and Kallioniemi OP (1998) Molecular cytogenetics of primary breast cancer by CGH. Genes Chromosomes Cancer 21: 177–184
Tsuda H, Takarabe T, Hasegawa T, Murata T and Hirohashi S (1999) Myoepithelial differentiation in high-grade invasive ductal carcinoma with large central acellular zones. Hum Pathol 30: 1134–1139
Tsuda H, Takarabe T, Hasegawa F, Fukotomi T and Hirohashi S (2000) Large, acellular zones indicating myocpithelial tumor differentiation in high-grade invasive ductal carcinomas as markers of predisposition to lung and brain metastases. Am J Surg Pathol 24: 197–202
Wells D, Sherlock JK, Handyside AH and Delhanty JDA (1999) Detailed chromosomal and molecular genetic analysis of single cells by whole genome amplification and comparative genomic hybridization. Nucleic Acids Res 27: 1214–1218
Wetzels RHW, Kuijpers HJH, Lane EB, Leigh IM, Troyanovsky SM, Holland R, van Haelst UJGM and Ramaekers FCS (1991) Basal cell-specific and hyperproliferation-related keratins in human breast cancer. Am J Pathol 138: 751–763
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Jones, C., Nonni, A., Fulford, L. et al. CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation. Br J Cancer 85, 422–427 (2001). https://doi.org/10.1054/bjoc.2001.1869
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DOI: https://doi.org/10.1054/bjoc.2001.1869
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