Abstract
If infections are involved in the aetiology of childhood leukaemia then seasonal variation in the birth or onset dates of the malignancy may be apparent. Previous studies that have examined seasonality of these dates have produced conflicting results. Using population-based data from the National Registry of Childhood Tumours we conducted a larger study than any to date of 15 835 cases of childhood leukaemia born and diagnosed in the UK between 1953–95. We found no evidence of seasonality in either month of birth or month of diagnosis overall or in any subgroups by age, sex, histology or immunophenotype. We did however find a significant (P= 0.01) February peak in month of birth for cases born before 1960 and a significant (P= 0.02) August peak in month of diagnosis for those diagnosed before 1962. Whilst these findings may be due to chance they are also consistent with changes over time in the seasonality of exposure, or immunological response, to a relevant infection. Changes in the seasonal variation in the fatality rate of a pre-leukaemic illness, such as pneumonia, could be another explanation. © 2001 Cancer Research Campaign http://www.bjcancer.com
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References
Badrinath P, Day NE and Stockton D (1997) Seasonality in the diagnosis of acute lymphocytic leukaemia. Br J Cancer 75: 1711–1713
Bailar JC and Gurian JM (1964) Month of birth and cancer mortality. J Natl Cancer Inst 33: 237–242
Bjelke E (1964) Leukaemia in children and young adults in Norway. Cancer 17: 248–255
Dickinson HO and Parker L (1999) Quantifying the effect of population mixing on childhood leukaemia risk: the Seascale cluster. Br J Cancer 81: 144–151
Doll R (1999) The Seascale cluster: a probable explanation. Br J Cancer 81: 3–5
Douglas S, Cortina-Borja M and Cartwright R (1999) A quest for seasonality in presentation of leukaemia and non-Hodgkin’s lymphoma. Leuk Lymph 32: 523–532
Ederer F, Miller RW, Scotto J and Bailar JC (1965) Birth-month and infant cancer mortality (letter to the editor). Lancet 2: 185–186
Edwards JH (1961) The recognition and estimation of cyclic trends. Ann Hum Genet Lond 25: 83–87
Fekety FR and Carey JJH (1969) Season and the onset of acute childhood leukaemia. Maryland State Med J 11: 73–77
Fraumeni JF (1963) Seasonal variation in leukaemia incidence (letter to the editor). Br Med J 2: 1408–1409
Gilman EA, Sorahan T, Lancashire RJ, Lawrence GM and Cheng KK (1998) Seasonality in the presentation of acute lymphoid leukaemia (letter to the editor). Br J Cancer 77: 677–678
Greaves MF (1997) Aetiology of acute leukaemia. Lancet 349: 344–349
Gunz, and Spears, (1968) Distribution of acute leukaemia in time and space. Studies in New Zealand. Br Med J 4: 604–608
Harris RE and Al-Rashid R (1984) Seasonal variation in the incidence of childhood acute lymphocytic leukaemia in Nebraska. Nebraska Med J 6: 192–198
Harris RE, Harrell FE, Kashineth DP and Al-Rashid R (1987) The seasonal risk of pediatric/ juvenile acute lymphocytic leukemia in the United States. J Chron Dis 40: 915–923
Hayes DM (1961) The seasonal incidence of acute leukaemia. Cancer 14: 1301–1305
Kellett CE (1937) Acute myeloid leukaemia in one of identical twins. Arch Dis Childh 12: 239–252
Kinlen LJ (1995) Epidemiological evidence for an infective basis in childhood leukaemia. Br J Cancer 71: 1–5
Knox G (1964) Epidemiology of childhood leukaemia in Northumberland and Durham. Brit J Prev Soc Med 18: 17–24
Lanzkowsky P (1964) Variation in leukaemia incidence (letter to the editor). Br Med J 1: 910
Lee JAH (1962) Seasonal variation in clinical onset of leukaemia in young people. Br Med J 1: 1737–1738
Machin D and Gao F (2000) Seasonal variations in the diagnosis of childhood cancer (letter to the editor). Br J Cancer 83: 699–700
Mainwaring D (1996) Epidemiology of acute leukaemia of childhood in the Liverpool area. Brit J Prev Soc Med 20: 189–194
Marrero O (1983) The performance of several statistical tests for seasonality in monthly data. J Statist Comput Simul 17: 275–296
Meltzer AA, Spitz MR, Johnson CC and Culbert SJ (1989) Season-of-birth and acute leukaemia of infancy. Chronobiol Int 6: 285–289
Meltzer AA, Annegers JF and Spitz MR (1996) Month of birth and incidence of acute lymphoblastic leukaemia in children. Leuk Lymph 23: 85–92
Office of Population Censuses and Surveys (1976–1997). Birth Statistics 1974–1995. Series FM1 no. 1–24. 1–24. HMSO, London
Registrar General (1955–1959). Registrar General’s Statistical Review of England and Wales (1953–1957). Tables. Part II. Civil. HMSO, London
Registrar General (1960–1975). Registrar General’s Statistical Review of England and Wales 1958–73.Tables Part II. Tables Population, HMSO, London
Ross JA, Severson RK, Swensen AR, Pollock BH, Gurney JG and Robison LL (1999) Seasonal variations in the diagnosis of childhood cancer in the United States. Br J Cancer 81: 549–553
Stark CR and Mantel N (1967) Temporal-spatial distribution of birth dates for Michigan children with leukaemia. Cancer Res 27: 1749–1755
StataCorp (1997). Stata Statistical Software: Release 5.0. College Station, TX: Stata Corporation
Stewart A (1975) Infant leukaemias and cot deaths. Br Med J 2: 605–607
Stewart A and Kneale GW (1969) Role of local infections in the recognition of haemopoietic neoplasms. Nature 223: 741–742
Stiller CA, Allen MB and Eatock EM (1995) Childhood cancer in Britain: the National Registry of Childhood Tumours and incidence rates. (1978–1987). Eur J Cancer 31: 2028–2034
Thorne R, Hunt LP and Mott MG (1998) Seasonality in the diagnosis of childhood acute lymphoblastic leukaemia (letter to the editor). Br J Cancer 77: 678
Till MM, Hardisty RM, Pike MC and Doll R (1967) Childhood leukaemia in Greater London: a search for evidence of clustering. Br Med J 3: 755–758
Van Steensel-Moll HA, Valkenburg HA, Vandenbroucke JP and Van Zanen GE (1983) Time space distribution of childhood leukaemia in the Netherlands. J Epidemiol Comm Health 37: 145–148
Vianna NJ and Polan AK (1976) Childhood lymphatic leukaemia: Prenatal seasonality and possible association with congenital varicella. Am J Epidemiol 103: 321–332
Walker AM and Van Noord PAH (1982) No seasonality in the diagnosis of acute leukeamia in the United States. J Natl Cancer Inst 69: 1283–1287
Westerbeek RMC, Blair V, Eden OB, Stevens RF, Will AM, Taylor GM and Birch JM (1998) Seasonal variations in the onset of childhood leukaemia and lymphoma. Br J Cancer 78: 119–124
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Higgins, C., dos-Santos-Silva, I., Stiller, C. et al. Season of birth and diagnosis of children with leukaemia: an analysis of over 15 000 UK cases occurring from 1953-95. Br J Cancer 84, 406–412 (2001). https://doi.org/10.1054/bjoc.2000.1575
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DOI: https://doi.org/10.1054/bjoc.2000.1575
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