Abstract
The relation between body mass (BMI) and soft-tissue sarcoma (STS) risk was evaluated in a case–control study from Northern Italy based on 217 incident STS and 1297 hospital controls. The risk of STS rose with BMI, with multivariate odds ratios of 3.49 (95% confidence interval (CI) 1.06–11.55) among men and 3.26 (95% CI 1.27–8.35) among women with a BMI >30 kg m–2 compared to those with BMI ≤ 20 kg m–2.
Similar content being viewed by others
Article PDF
Change history
16 November 2011
This paper was modified 12 months after initial publication to switch to Creative Commons licence terms, as noted at publication
References
Benn, RT (1971) Some mathematical properties of weight-for-height indices used as measures of adiposity. Br J Prev Soc Med 25: 42–50.
Bertazzi, PA, Pesatori, AC, Consonni, D, Tironi, A, Landi, MT & Zocchetti, C (1993) Cancer incidence in a population accidentally exposed to 2,3,7,8-tetrachlorodibenzo-para-dioxin. Epidemiology 4: 398–406.
Breslow, NE & Day, NE (1980). Statistical Methods in Cancer Research. Vol. 1. The Analysis of Case–control Studies, IARC Scientific Publication 32: IARC: Geneva, pp. 1–279.
Daughaday, WH (1990) The possible autocrine/paracrine and endocrine roles of insulin-like growth factors of human tumors. Endocrinology 127: 1–4.
Friedman, JM (1997) The alphabet of weight control. Nature 385: 119–120.
Galuska, DA, Serdula, M, Pamuk, E, Siegel, PZ & Byers, T (1996) Trends in overweight among US adults from 1987 to 1993: a multistate telephone survey. Am J Public Health 86: 1729–1735.
Hoar, SK, Blair, A, Holmes, FF, Boysen, CD, Robel, RJ, Hoover, R & Fraumeni, JF Jr (1986) Agricultural herbicide use and risk of lymphoma and soft-tissue sarcoma. JAMA 256: 1141–1147.
Hoppin, JA, Tolbert, PE & Herrick, RF et al (1998) Occupational chlorophenol exposure and soft tissue sarcoma risk among men aged 30–60 years. Am J Epidemiol 148: 693–703.
Kang, H, Enziger, F, Breslin, P, Feil, M, Lee, Y & Shepard, B (1987) Soft tissue sarcoma and military service in Vietnam: a case–control study. J Natl Cancer Inst 79: 693–699.
Kang, HK, Watanabe, KK & Breen, J et al (1991) Dioxins and dibenzofurans in adipose tissue of US Vietnam veterans and controls. Am J Public Health 81: 344–349.
Kogevinas, M, Becher, H & Benn, T et al (1997) Cancer mortality in workers exposed to phenoxy herbicides, chlorophenols, and dioxins. An expanded and updated international cohort study. Am J Epidemiol 145: 1061–1075.
La Vecchia, C, Lucchini, F, Negri, E, Boyle, P, Maisonneuve, P & Levi, F (1992) Trends of cancer mortality in Europe, 1955–1989: II, respiratory tract, bone, connective and soft tissue sarcomas, and skin. Eur J Cancer 28: 514–599.
Lew, EA & Garfinkel, L (1979) Variations in mortality by weight among 750,000 men and women. J Chron Dis 32: 563–576.
Manson, JE, Stampfer, MJ, Hennekens, CH & Willett, WC (1987) Body weight and longevity. A reassessment. JAMA 257: 353–358.
Mantzoros, CS, Tzonou, A & Signorello, LB et al (1997) Insulin-like growth factors 1 in relation to prostate cancer and benign prostatic hyperplasia. Br J Cancer 76: 1115–1118.
Millar, WJ (1986) Distribution of body weight and height: comparison of estimates based on self-reported and observed measures. J Epidemiol Community Health 40: 319–323.
Negri, E, Pagano, R, Decarli, A & La Vecchia, C (1988) Body weight and the prevalence of chronic diseases. J Epidemiol Community Health 42: 24–29.
Nieto-Garcia, FJ, Bush, TL & Keyl, PM (1990) Body mass definitions of obesity: sensitivity and specificity using self-reported weight and height. Epidemiology 1: 146–152.
Orban, JE, Stanley, JS, Schwemberger, JG & Remmers, JC (1994) Dioxins and dibenzofurans in adipose tissue of the general US population and selected subpopulations. Am J Public Health 84: 439–445.
Pagano, R, La Vecchia, C, Decarli, A, Negri, E & Franceschi, S (1997) Trends in overweight and obesity among Italian adults, 1983 through 1994. Am J Public Health 87: 1869–1870.
Palta, M, Prineas, RJ, Berman, R & Hannan, P (1982) Comparison of self-reported and measured height and weight. Am J Epidemiol 115: 223–230.
Patterson, DG Jr, Hoffman, RE & Needham, LL et al (1986) 2,3,7,8-tetrachlorodibenzo-p-dioxin levels in adipose tissue of exposed and control persons in Missouri. An interim report. JAMA 256: 2683–2686.
Petridou, E, Dessypris, N & Spanos, E et al (1999) Insulin-like growth factor-I and binding protein-3 in relation to childhood leukaemia. Int J Cancer 80: 494–496.
Reif, J, Pearce, N, Kawachi, I & Fraser, J (1989) Soft-tissue sarcoma, non-Hodgkin’s lymphoma and other cancers in New Zealand forestry workers. Int J Cancer 43: 49–54.
Ross, JA, Severson, RK, Davis, S & Brooks, JJ (1993) Trends in the incidence of soft tissue sarcomas in the United States from 1973 through 1987. Cancer 72: 486–490.
Saracci, R, Kogevinas, M & Bertazzi, PA et al (1991) Cancer mortality in workers exposed to chlorophenoxy herbicides and chlorophenols. Lancet 338: 1027–1032.
Serraino, D, Franceschi, S, Talamini, R, Frustaci, S & La Vecchia, C (1991) Non-occupational risk factors for adult soft-tissue sarcoma in northern Italy. Cancer Causes Control 1: 157–164.
Stewart, AL (1982) The reliability and validity of self-reported weight and height. J Chron Dis 35: 295–309.
Tavani, A, Pregnolato, A & Negri, E et al (1997) Diet and risk of lymphoid neoplasms and soft tissue sarcomas. Nutr Cancer 27: 256–260.
Tritos, NA & Mantzoros, CS (1998) Recombinant human growth hormone: old and novel uses. Am J Med 105: 44–57.
Woods, JS, Polissar, L, Severson, RK, Heuser, LS & Kulander, BG (1987) Soft tissue sarcoma and non-Hodgkin’s lymphoma in relation to phenoxyherbicide and chlorinated phenol exposure in Western Washington. J Natl Cancer Inst 78: 899–910.
Zahm, SH, Blair, A, Holmes, FF, Boysen, CD, Robel, RJ & Fraumeni, JF Jr (1989) A case–control study of soft-tissue sarcoma. Am J Epidemiol 130: 665–674.
Zahm, SH & Fraumeni, JF Jr (1997) The epidemiology of soft tissue sarcomas. Semin Oncol 24: 504–514.
Zahm, SH, Tucker, MA & Fraumeni, JF Jr (1996). Soft tissue sarcomas. In: Cancer by Tissue Origin, Schottenfeld D and Fraumeni JF Jr (eds) pp. 984–999. Oxford University Press: New York
Author information
Authors and Affiliations
Rights and permissions
From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
About this article
Cite this article
Tavani, A., Soler, M., Vecchia, C. et al. Body weight and risk of soft-tissue sarcoma. Br J Cancer 81, 890–892 (1999). https://doi.org/10.1038/sj.bjc.6690781
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bjc.6690781
Keywords
This article is cited by
-
Incidence of second sarcomas: a cancer registry-based study
Cancer Causes & Control (2014)
-
Oral contraceptive use, parity, and constitutional characteristics in soft tissue sarcoma: a Swedish population-based case–control study 1988–2009
Cancer Causes & Control (2014)
-
Relation of body mass index to cancer risk in 362,552 Swedish men
Cancer Causes & Control (2006)
-
Primary multidisciplinary management of extremity soft tissue sarcomas
Current Treatment Options in Oncology (2004)