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Association study of myo-inositol monophosphatase 2 (IMPA2) polymorphisms with bipolar affective disorder and response to lithium treatment

The Pharmacogenomics Journal volume 5, pages 35–41 (2005)Cite this article

Abstract

Lithium is the most effective mood-stabilizing drug in the therapy of bipolar affective disorder (BP). It is thought to exert its effect via the phosphatidylinositol signalling system. Myo-inositol monophosphatase 2 (IMPA2) codes for an enzyme in this system that is inhibited by lithium. It is located on 18p11.2, a region implicated as a BP susceptibility locus. We examined eight single-nucleotide polymorphisms (SNPs) identified within this gene for association with BP, using 237 parents–offspring trios and in 174 cases and 170 controls. No SNP showed association with BP. When good responders to lithium treatment were compared with the poor responders, some statistically significant differences emerged for two SNPs; however, the sample became too small to draw definitive conclusions. We cannot find support for the involvement of variation in IMPA2 in susceptibility to bipolar disorder, but the role of this and other genes from the phosphoinositol signalling pathway in predicting response to lithium treatment merits further investigation.

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Acknowledgements

We thank all the patients and their parents who took part in the study.

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Authors and Affiliations

  1. Department of Medical Genetics, Medical University Sofia, Sofia, Bulgaria

    A Dimitrova & D Toncheva

  2. Clinic of Psychiatry, Medical University, Sofia, Bulgaria

    V Milanova & S Krastev

  3. Neuropsychiatric Genetics Unit, University of Wales College of Medicine, Heath Park, Cardiff, UK

    I Nikolov, M J Owen & G Kirov

Authors
  1. A Dimitrova
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  2. V Milanova
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  3. S Krastev
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  4. I Nikolov
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  5. D Toncheva
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  6. M J Owen
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  7. G Kirov
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Corresponding author

Correspondence to G Kirov.

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Dimitrova, A., Milanova, V., Krastev, S. et al. Association study of myo-inositol monophosphatase 2 (IMPA2) polymorphisms with bipolar affective disorder and response to lithium treatment. Pharmacogenomics J 5, 35–41 (2005). https://doi.org/10.1038/sj.tpj.6500273

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