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A complicated relationship: fulfilling the interactive needs of the T lymphocyte and the dendritic cell

The Pharmacogenomics Journal volume 2, pages 367–376 (2002)Cite this article

Abstract

T cells recognize antigenic peptides displayed on the surface of MHC-bearing antigen-presenting cells (APCs), and with sufficient costimulation become activated. However, the ability of an APC (even bearing the correct peptide) to initiate and fulfill the requirements for T cell activation is not easily achieved. Naive T cells use multiple copies of a single receptor to survey the vast array of peptides presented on an APC, and require multiple receptor engagements to initiate T cell activation. Dendritic cells (DCs) are specialized cells with optimal capabilities for priming naive CD4+ T cells. Activation occurs, after initial antigen recognition by T cells, followed by a rapid dialogue between the T cells and the DCs. The resulting changes in both the cytoskeleton and the expression or regulation of cell-surface molecules on both cell types act to further strengthen engagement. In this report, we review the fundamentals of CD4+ T helper cell : DC interactions and discuss recent data concerning the molecular characteristics of this engagement.

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We thank Dr Edgar Engleman for comments and reviewing of the manuscript.

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  1. Department of Medicine, Division of Immunology and Rheumatology, Center for Clinical Immunology at Stanford (CCIS), Stanford University School of Medicine, Palo Alto, CA, USA

    JM McBride & CG Fathman

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McBride, J., Fathman, C. A complicated relationship: fulfilling the interactive needs of the T lymphocyte and the dendritic cell. Pharmacogenomics J 2, 367–376 (2002). https://doi.org/10.1038/sj.tpj.6500145

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